Both herpes simplex virus type 1 and 2 (HSV-1 and HSV-2) cause genital herpes, a chronic infection characterized by recurrent, self-limited genital ulcers. Genital herpes is associated with large medical, social, and financial burdens. In ...
Genital HSV-1 shedding was detected on 12.1% of days at 2 months and declined significantly to 7.1% of days at 11 months. Most genital shedding was asymptomatic; genital and oral lesions and oral shedding were rare. Meaning Genital HSV-1 shedding was frequent after first-episode genital HSV-...
Stanfield et al., A Single Intramuscular Vaccination of Mice with the HSV-1 VC2 Virus with Mutations in the Glycoprotein K and the Membrane Protein UL20 Confers Full Protection against Lethal Intravaginal Challenge with Virulent HSV-1 and HSV-2 Strains, PLoS One (2014) 9(10): 1-13. Stanf...