Results We estimate that in 2012, 417 million people aged 15–49 years (range: 274–678 million) had existing HSV-2 infection world-wide: a global prevalence of 11.3%. Of those infected, 267 million were women. Also in 2012, we estimate that 19.2 million (range: 13.0–28.6 million) ...
we found that circulating HSV-2 strains can contain HSV-1 DNA segments in three distinct genes. Using over 150 genital swabs from North and South America and Africa, we detected recombinants
The high similarity between the HSV-2 strain 19080 and HSV-1 in the recombinant fragment was also shown by Simplot analysis. Similar results for a shorter recombinant fragment were observed for HSV-2 strain HG52 (Fig. 3). The phi-statistics for the presence of recombination had p-values ...
Results In this paper, we formulate a multi-group SVIRI epidemic model for HSV-2, which enables us to consider the effects of vaccination, of waning vaccine immunity, and of infection relapse. Since the number of groups is arbitrary, our model can be applied to various structures such as ri...
The development of a faster, high throughput microneutralization assay (MNA) for HSV-2 viruses carried out in a 96-well format will allow for rapid testing of large numbers of samples for drug and vaccine development. Methods We describe the generation of a MNA that utilizes a pair of anti-...
Source Function Library HSV to RGB Test Hue Cycle HSV Adjustment So far we always used RGB colors in our shaders, meaning the components of our color vector always map to the red green and blue components of the color. This is great if we want to render the color or tint it, but adj...
3.2.2. Latent virus The results of the qPCR evaluations revealed only a small and not significant reduction in latent HSV-2 DNA (−11.7% in dorsal root ganglia (DRG) and −6.3% in spinal cord (SC)) in the IM-250 treated groups. As shown inFig. 3, the viral load in the DRG ...
Primers for conventional PCR were designed to detect HSV-1 and -2 and varicella zoster virus (VZV). RESULTS: Significantly higher copy number of HSV DNA was detected in corneas with a history of herpetic keratitis 85.7% (6/7), with an average of 1.6 x 10(4) copies/mg tissue weight ...
The ability of the HSV-1 R2 virus to invade neural tissue from the genital tract and to provide protection from subsequent intravaginal (IVag) HSV-2 challenge were assessed. Results Lack of R2 virulence Following IVag inoculation, despite replicating with similar but slightly reduced kinetics in ...
Results Early virus-independent recruitment of neutrophils to HSV-infected skin. Neutrophils infil- trate the skin after epicutaneous HSV-1 infection with their numbers peaking 5 days after the initial infection9. However, the kinetics of their influx into the skin and draining LNs during the ...