Herpes simplex virus type 1 (HSV-1) plays an important role in the field of gene therapy and viral vaccines, especially as an oncolytic virus. However, the
Dosing should be adjusted in all patients if the everolimus whole blood trough level is below 3 ng/ml or above 6 ng/ml (a tolerance of ±10% in the target trough level is allowed for a period of 8 weeks) and below 2 ng/ml or above 5 ng/ml (a tolerance of ±10% in the target...
Figure 1. Recruitment and activation of pDCs in inflamed LNs. (A) The frequency (top) and the absolute numbers (bottom) of B220+CD11c+ pDCs in PLNs (rt. PLN) from uninfected (d0) or HSV-infected mice on day 2 (d2). (B) Expression of CD86, CD40, and CD40L on blood pDC precur...
Blood was collected by cardiac puncture into serum separator tubes and centrifuged for 10 min at 3000 rpm. Sera and tissues, including brain, liver, kidney, and injection site skin, were collected in 4% PFA and subjected to immunological and histological analyses. 2.3. Assessment Of HSV-2 ...
Blood HSV-1-DNA was positive in 3/13 patients. All the three patients with positive HSV-1-DNA on blood had HSV-1 reactivation detected on BALF samples. Table 2. Univariable and multivariable analyses of potential predictors of HSV-1 reactivation *. The crude 30-day mortality in the study...