Serum was tested for HSV-specific IgG antibodies at enrollment and at 12, 24, and 52 weeks using the University of Washington Western Blot, which differentiates between HSV-1 and HSV-2 infection.8Samples were considered HSV-1 or HSV-2 p...
Since the antibody against HSV-2 infection (IgG) provides life-long immunity [35], we fitted I+R to the observed data of the number of sero-positive cases for the estimation of c and ϕ. To estimate c and ϕ, endemic equilibria of I i and R i were solved numerically with varied...
By 52 weeks, 60 of 63 participants (95.2%) were HSV-1 seropositive, 1 (1.6%) remained HSV-1 negative, and 2 (3.2%) remained indeterminate. All participants remained HSV-2 seronegative throughout the study. Genital Shedding and Lesions All participants completed session 1 and 64 (78.1%) ...