Mckie EA,MeKie EA,MacLean AR,Lewis AD,et al.Selective in vitro replication of herpes simplex virus type 1 (HSV-1) ICP34. 5 null mutants in primary human CNS tumours--evaluation of a potentially effective clinical therapy.British Journal of Cancer. 1996...
In particular, HSV-1 counteracts the autophagic response in fibroblasts3 and in primary neurons4 by the infected cell protein 34.5 (ICP34.5) which directly binds to Beclin1, preventing its functions3,5. The Us11 protein also inhibits auto- phagy induction in both HeLa cells and fibroblasts, ...
ICP34.5(γ34为.5双)拷贝的神经毒基因 (由RL1编码),其编码产物为HSV-1在神经细 胞中增殖所必需的,当双拷贝ICP34.5基因被删除时,病毒在神经细胞及其他生长缓慢的 细胞中的复制被抑制, 但在快速分裂的细胞中能高效复制增殖。γ34.5基因是病毒的毒性基 因,其主要功能是阻断病毒感染过程中宿主细胞关闭蛋白质的合成...
However, HSV-1, a large DNA virus, can evade the innate immune response and ultimately establish a latent infection status in host cells, aided by its over 80 viral proteins.13,14 It has been demonstrated that the immediate-early protein known as infected cell protein 0 (ICP0) plays a ...
bisque1 #ffe4c4 255,228,196 0.0904,0.2314,1.0000 0.0000,0.1059,0.2314,0.0000 bisque2 #eed5b7 238,213,183 0.0909,0.2311,0.9333 0.0000,0.1050,0.2311,0.0667 bisque3 #cdb79e 205,183,158 0.0887,0.2293,0.8039 0.0000,0.1073,0.2293,0.1961 bisque4 #8b7d6b 139,125,107 0.0938,0.2302,0.5451 0.0000,...
Molecular Biomedicine (2024) 5:35 Page 6 of 30 E and L genes are suppressed by ND10 bodies and the HCLR repressor complex, which is composed of histone deacetylases (HDAC1 or HDAC2), Co-RE1 silencing transcription factor (CoREST), LSD1, and REST. ICP0, however, disrupts this ...
OHSV2是一种n型单纯疱疹病毒，其在标准株HSV-2(HG52)的基础上,敲除了ICP47基因及ICP34.5基因并插入了粒细胞-巨噬细胞集落刺激因子(human granulocyte-macrophage colony stimulating factor,hGM-CSF)，从而使病毒可以在肿瘤细胞内选择性复制，促进抗原递呈并且提高了病毒的溶瘤活性⑷。oHSV2具有直接的细胞毒...
NO:5的氨 基酸序列具有80%或更高同一性的氨基酸序列的HSV糖蛋白E(gE)或其免疫原性片段,或其 任何组合。 5.根据权利要求4所述的疫苗组合物,其包含: (i)UL48和gD和/或gB,任选的ICP4; (ii)UL48和UL49与gE; (iii)UL11、UL16和UL21与gE、gD和/或gB;或 (iv)UL31和UL34与gD和/或gB。 6.根据权...
Virus growth curves in HSV-1-infected HeLa cells (MOI 0.5) depleted for members of the MC signalling pathway were plotted and compared to negative (mock-transfected) and positive controls (ICP4, an essential HSV-1 gene). (d) HSV-1 is inhibited by overexpression of MC signalling pathway ...
The figure is based on HSV-1 complete genome sequence (Accession no. X14112). LAT TRE ChIP primers were designed adjacent to one end. Cell Research | Vol 20 No 5 | May 2010 Liganded TR positively regulated LAT but repressed ICP0 transcription The regulatory effect of TR on LAT and ICP...