METHODS: Two mutants, genetically constructed from HSV-1 strain 17syn+, were used to inoculate rabbit corneas: 17deltaPst, a latency associated transcript (LAT) negative, low-reactivating virus and 17Pr, a high-reactivating, LAT-positive rescuant of 17deltaPst. Latently infected rabbits were ...
Bolovan CA, Sawtell NM, Thompson RL . ICP34.5 mutants of herpes simplex virus type 1 strain 17syn+ are attenuated for neurovirulence in mice and for replication in confluent primary mouse embryo cell cultures.J Virol1994;68: 48–55. ArticleCASPubMedPubMed CentralGoogle Scholar Wakimoto H, J...
Development of a syngenic murine B16 cell line-derived melanoma susceptible to destruction by neuroattenuated HSV-1. Mol. Ther - Miller, Krummenacher, et al. - 2001 () Citation Context ... of the present study was to monitor the fate of the glycoproteins during the first 10 min of entry...
PURPOSE: The anti-tumor properties of thalidomide or in combination with an oncolytic herpes virus (OncdSyn) was investigated in a mouse model of human breast cancer. METHODS: To determine if thalidomide could act alone, 4T1 cells were injected into Balb/c mice. Tumors were sized, and the ...
The same point mutation within region II of the herpes simplex virus type 1 (HSV-1) DNA polymerase gene confers resistance to foscarnet (PFA) and the phosphonylmethoxyethyl (PME) derivatives of adenine (PMEA) and 2,6-diaminopurine (PMEDAP)...
此次研究中,科学家们开发了新的合成平台,利用酵母的转化重组技术,加速了HSV-1病毒的合成过程,从而大幅提高了效率,并有效降低了安全风险。研究团队成功构建了一个名为F-Syn的合成病毒,其病原生物学特性与自然病毒相似,显示出良好的应用前景。 不仅如此,研究还结合了CRISPR/Cas9技术,创造出了一种缺失关键病毒基因的改...
The present study was performed to determine the effect of propranolol on epinephrine iontophoresis-induced ocular recurrence and immunosuppression-induced ocular recurrence in the rabbit eye model.New Zealand white rabbits were infected with HSV-1 strain 17Syn+ or McKrae. After latency was established...
Significantly, individuals who underwent specialized facial therapy exhibited significant enhancements in facial nerve function, a decrease in synkinesis episodes, and better scores suggesting improved quality of life compared to those who received standard care. Additionally, this p...
Spontaneous ocular shedding and adrenergic induction of ocular shedding were examined in rabbits infected with ten strains of herpes simplex virus type 1 (HSV-1): McKrae, KOS, F, Rodanus, 17 Syn+, RE, E-43, SC-16, MacIntyre, and CGA-3. All ocular inoculations were with 50 1 of ...
We examined whether immunization with the nonpathogenic strain R-15 of herpes simplex virus-1 (HSV-1) may prevent the clinical and neuroendocrine changes induced by the pathogenic HSV-1 strain Syn17+. Inoculation of strain Syn17+ to control rats induced fever, marked motor hyperactivity and ...