The full activation of HSF1 trimers is further regulated by an array of post-translational modifications involving hyper-phosphorylation and sumoylation. Phosphorylation of human HSF1 on serine residues 230, 326, and 419 promotes its transcriptional activity (Pirkkala et al., 2001), whereas ...
Sign in to download full-size image Fig. 11.5. The motif structure of Drosophila HSF1 protein and the three dimensional ribbon structure of DNA binding domain in Drosophila HSF1 (amino acid residue 45–150). β1 to β4 indicates the different β-strand regions and H1 to H3 indicates differ...
Full size image To provide a high resolution view of chromatin architecture in tomato, we performed Hi-C, a genome-wide method to detect DNA-DNA physical interactions8. We observed a strong signal on the main diagonal, indicating frequent interactions between adjacent loci (Fig. 1b). The Hi...
the activity of HSF proteins is also highly relevant for aging and tumorigenesis18,19. While yeast only has one HSF and vertebrates have up to 4, this gene family has radiated massively in higher plants26. Of the 21 HSF genes
Full size image Analysis of cis-acting elements in ScHSF promoters The promoter regions of ScHSFs were analyzed to provide ideas for tissue-specific expression of genes and stress response patterns. The cis-acting elements in promoter could be divided into four categories: light-responsive, hormone...
HSF2 on the other hand is similar to mouse HSF1, as it exists as two isoforms, the alpha form being more transcriptionally active than the smaller beta form (7, 8). Various experiments have suggested that HFS2 may have roles in differentiation and development (9, 10, 11). References :...
White adipose tissue (WAT), the predominant fat form in obesity, serves chiefly as an energy store, accumulating lipids predominantly as triglycerides [6]. Excess energy prompts white adipocytes to enlarge via augmented lipid storage, occasionally surpassing their healthy expansion threshold, culminating...
High-quality images were selected. Several pathology experts measured the length of the neoepithelium in a blinded fashion. Western blot and immunohistochemical staining detection of SBPP1/HSF1 expression Fourteen days after the injury, 10 mm × 10 mm samples were taken from the full-...
L. Impaired heat shock response in cells expressing full-length polyglutamine-expanded Huntingtin. PLoS ONE 7, e37929 (2012). Article ADS CAS Google Scholar Riva, L. et al. Poly-glutamine expanded huntingtin dramatically alters the genome wide binding of HSF1. J. Huntingtons Dis. 1, 33–...
Fibronectin is an extracellular matrix glycoprotein with key roles in cell adhesion and migration. Hsp90 binds directly to fibronectin and Hsp90 depletion regulates fibronectin matrix stability. Where inhibition of Hsp90 with a C-terminal inhibitor, novo