免疫组化(immunohistochemistry,IHC)H-score是一种常用于评估蛋白质表达水平的方法,特别是在肿瘤研究中被广泛应用。H-score是通过对组织切片进行免疫组化染色后,根据染色强度和阳性细胞的百分比来计算得出的分级结果。 在进行免疫组化染色后,通常会对切片中的细胞进行评分。评分的标准可以根据染色强度和阳性细胞的百分比来...
免疫组化(immunohistochemistry,IHC)是一种利用抗体识别特定蛋白质在组织切片中的表达情况的技术。在癌症研究和临床诊断中,免疫组化技术被广泛应用于研究蛋白质的表达水平和分布。而在免疫组化数据的分析中,H-score和平均光密度(average optical density,AOD)作为重要的评价指标,可以帮助我们更精确地分析免疫组化结果。
Quantification of protein expression in IHC is typically assessed with H-scores, calculated by a pathologist on a scale from 0 to 300 based on the intensity of carcinoma cells and their relative proportion.The subjectivity of the methodology is an inherent risk of inconsistency for inter- intra-...
Stratification of IHC score 0/1+ tumors and amplification status by SISH to overall survival. Z Varga,RR Tubbs,H Moch 被引量: 0发表: 2014年 Malignant peripheral nerve sheath tumors in patients with and without neurofibromatosis. Malignant peripheral nerve sheath tumors (MPNST) are rare. They ...
HscoreNet: A Deep Network for Estrogen and Progesterone Scoring Using Breast IHC ImagesBreastEstrogenProgesteroneEncoderDecoderEstrogen and progesterone receptors serve as an important predictive and prognostic biomarkers for breast cancer immunohistological analysis. For breast cancer prognosis, pathologists ...
Validation of Automated H-Score Wholeslide Analysis of CEA-Expressing Tumor Cells in IHC Brightfield ImagingLorsakul, AuranuchYao NieAndersson, EmiliaKlaman, IrinaJournal of Pathology Informatics
Thus, in the present investigation, three well-established semi-quantitative scoring systems [immunoreactive score (IRS), human epidermal growth factor receptor 2 (HER2)/neu score, H score] used commonly for SSTR-IHC evaluation in NEN were compared.Specht, ElisaKaemmerer, DanielSaenger, JoergWirtz...
From this initial image dataset, 240 regions of interest (ROIs) were manually selected in order to create a dataset that uniformly covers: (i) all HER2-IHC scores (0-3), (ii) a wide range of HER2 stain intensities, and (iii) expression patterns. The IHC scores were assigned to each ...
IHCpreanalytical variationtheranosticsDigital quantitative immunohistochemical analysis of protein biomarker expression offers a broad dynamic range against which clinical outcomes may be measured. Semi-quantitative expression data represented as an H-score is produced by computer generated average intensity of ...