本发明提供一种小分子非编码RNA(该小分子非编码RNA命名为hsa-miR-29b)及其应用.本发明进行了体外管形成实验和裸鼠成瘤及免疫组化实验,体外管形成实验的结果表明体外恢复hsa-miR-29b表达可显著抑制肿瘤细胞诱导的血管生成;裸鼠成瘤及免疫组化实验的结果表明体内恢复hsa-miR-29b表达可显著抑制肿瘤细胞的体内成瘤能力和...
早期非小细胞肺癌患者hsa—mir-34b基因启动子甲基化水平检测
Mechanically, we found that hsa_circ_000984 may act as a competing endogenous RNA (ceRNA) by competitively binding miR-106b and effectively upregulate the expression ofCDK6, thereby inducing a series of malignant phenotypes of tumor cells. Taken together, these observations suggest that the hsa_...
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Therefore, the hsa-miR-29b can be used for preparing medicines for inhibiting tumor cell induced angiogenesis, anti-tumor angiogenesis medicines, antitumor medicines and anti-tumor hematogenous metastasis medicines.周慧超庄诗美方坚鸿
ModrianskýSDOSToxicology in VitroKollinerova S, Dostal Z, Modriansky M. MicroRNA hsa-miR-29b potentiates etoposide toxicity in HeLa cells via down-regulation of Mcl-1. Toxicol In Vitro (2017) 40:289-96. doi: 10.1016/j.tiv.2017.02.005...
The expression of circHYBID-hsa-miR-29b-3p-transforming growth factor (TGF)-尾1 axis was examined by quantitative real-time polymerase chain reaction (qRT-PCR) and Western blotting. CircHYBID, TGF-尾1, and HA levels in cartilage samples were evaluated using qRT-PCR and pathological ...
Preterm birth (vs. full-term) was associated with adulthood levels of hsa-miR-29b-3p in a fully adjusted regression model (p=1.90脳10, FDR=0.046). The levels of hsa-miR-29b-3p were down-regulated in subjects with PTB with appropriate birthweight for gestational age (p=0.002, fold ...
Results. We have found that 35 miRNAs were differentially expressed in T2DM with D-IBS, in which three representative miRNAs, hsa-miR-106b, hsa-miR-26a, and hsa-miR-29b, were found to be significantly elevated in T2DM with D-IBS by RT-PCR. Conclusions. Our study has indicated that hsa...