DUSP1-overexpression and hsa-miR-141-3p-inhibition HeLa cells were established, and CCK-8, transwell, wound healing, cell cycle, and apoptosis assays were implemented. The targets of hsa-miR-141-3p were obtained with online tools, and the combination of hsa-miR-141-3p and DUSP1 was ...
Hsa_circ_0067301 knockdown could promote the proliferation and migration in Ishikawa and End1/E6E7 cells, concomitant with increased the relative protein expression against Notch-1, Hes-1, N-cadherin, and vimentin but reduced expression of E-cadherin. After co-transfection with the miR-141–5p ...
目的:探讨hsa-miR-199a-5p在缺血性脑卒中(IS)患者血清中的表达和意义.方法:收集118例IS患者及125例健康人群的血清标本.通过实时荧光定量PCR(q PCR)检测血清hsa-miR-199a-5p的表达,用ROC曲线分析hsa-miR-199a-5p表达应用于诊断IS的价值,并对hsa-miR-199a-5p表达与研究人群的临床特征进行相关性分析.结果:hsa...
《hsa-miR-141在鼻咽癌中的功能和分子网络机制研究》是依托中南大学，由周鸣担任项目负责人的面上项目。项目摘要 miRNA是一类小分子非编码RNA，以癌基因或抑癌基因角色参与肿瘤发生发展。has-miR-141是鼻咽癌中受c-Myc/BRD7轴正性调节的miRNA，在鼻咽癌中表达上调，具有促进鼻咽癌细胞恶性增殖的生物学功能。本项目拟...