目的观察hsa-miR-124-3p.1通过靶向肿瘤坏死因子受体相关因子6(TRAF6)抑制转化生长因子β1(TGF-β1)对人胃癌细胞上皮间质转化,迁移和侵袭的影响.方法收集胃癌组织和癌旁正常组织各43例,培养人胃黏膜上皮细胞GES-1及胃癌细胞NCI-N87,MGC-803,BGC-823,SGC-7901,MKN-45,采用荧光定量PCR技术和蛋白印迹法检测组织...
FULL PAPER British Journal of Cancer (2013) 108, 131–138 | doi: 10.1038/bjc.2012.537 Keywords: renal cell carcinoma; microRNA; mir-124-3; DNA methylation; prognosis Hsa-mir-124-3 CpG island methylation is associated with advanced tumours and disease recurrence of patients with clear cell ...
hsa-miR-124-3plncRNAmiRNAAcute lymphoblastic leukemia (ALL) is one of the deadly forms of childhood cancers in the world. In the present study, we used both in vitro and in vivo models to evaluate the functional mechanisms of a long noncoding RNA (lncRNA), small nucleolar RNA host gene...
目的 探究母体血液指标微小RNA200C(miR-200C),hsA-miR-124A-3p与常规血清标志物在孕中期唐氏综合征(DS)筛查中的临床价值.方法 选取我院2015年1月～2020年6月孕中期(14～27w)DS孕妇55例作为观察组,按照1:1原则随机选取正常妊娠孕妇55例作为对照组.比较两组一般资料,母体血液指标miR-200C,hsA-miR-... 查看...
这条通路会保持激活状态,并在宫颈高级别病变的发展过程中发挥作用。 特定基因启动子区甲基化,如hsa-miR-124-2,SOX-1, TERT, and LMX1A可以作为检测宫颈癌前病变的辅助手段,而且这项客观的检测方法可以利用宫颈细胞学和HPV DNA检测的样本。将甲基化谱分析与细胞学和HPV DNA联合更具预测性。
Among these, hsa-miR-124-3p shows significant potential as a prognostic marker for therapeutic efficacy in athletes, providing a new avenue for early detection and management of multiple myeloma in this specific population.Hui GongChunxiang Kang...
Hsa-mir-124-3 CpG island methylation is associated with advanced tumours and disease recurrence of patients with clear cell renal cell carcinoma [J]. BrJ Cancer, 2013, 108(1):131-138.Gebauer K, Peters I, Dubrowinskaja N, et al. Hsa ⁃ mir ⁃ 124 ⁃ 3 CpG island methylation is ...
Hsa-MicroRNA-124a-3p (hsa-miR-124-3p) is involved in tumor progression in certain malignant tumors. However, its function and clinical implication in hepatocellular carcinoma (HCC) have not yet been...doi:10.1007/s11033-018-4431-1Long, Hui-Deng...
Role of Hsa-miR-124 in Molecular Reprogramming and Therapeutic Effect Of Melatonin-miR-124 Combination In A Senescence-Related Secretory Phenotype (SAPS) Induced Vascular Atherosclerosis ModelGuclu, OrkutHuseyin, SerhatDoganlar, OguzhanChasan, Tourkian...
在干扰hsa_circ_0006950组细胞中同时下调miR-124-3p或过表达EZH2后,hsa_circ_0006950对细胞克隆形成及迁移的抑制作用被逆转恢复.结论 胰腺癌中hsa_circ_0006950显著高表达,抑制其表达可以抑制胰腺癌细胞的增殖及迁移;hsa_circ_0006950可能通过靶向下调miR-124-3p表达,进而上调EZH2表达来发挥作用,参与胰腺癌的发生发展...