(P<0.05).hsa-Let-7a-5p组的细胞增殖率,迁移能力均有所降低;hsa-Let-7a-5p组的Ⅰ,Ⅲ型胶原,α-SMA,TGF-β,p-Smad2/3的mRNA和蛋白表达水平均明显低于对照组(P<0.05).结论hsa-Let-7a-5p在体外通过靶向结合TGF-βR1调控TGF-β/Smad通路,抑制LSFs增殖与迁移,降低LSFs的纤维化标志物,从而抑制局限性硬皮病...
生物信息学分析表明hsa-Let-7a-5p可以与TGF-βR13′-UTR的靶区位置配对,hsa-Let-7a-5p慢病毒转染组的hsa-Let-7a-5p表达量明显高于对照组(P<0.05),TGF-βR1表达量明显降低(P<0.05).hsa-Let-7a-5p组的细胞增殖率,迁移能力均有所降低;hsa-Let-7a-5p组的Ⅰ,Ⅲ型胶原,α-SMA,TGF-β,p-Smad2/3的mRNA...
hsa_circ_0005519 increases il-13_il-6 by regulating hsa-let-7a-5p in cd4( ) t cells to affect asthma. (2019).[10.1111_cea.13445] 文档格式: .pdf 文档大小: 805.75K 文档页数: 12页 顶/踩数: 0/0 收藏人数: 0 评论次数: 0 文档热度: ...
let-7a-5p inhibitor promoted cell proliferation (P < 0.05) and inhibited cell apoptosis of PDLSCs (P < 0.01). Conclusion: hsa-let-7a-5p can inhibit the proliferation of PDLSCs and promote the apoptosis of PDLSCs.张晔琳马丽娅彭旭晖
Mechanistically, hsa_circ_0005519 might bind to hsa‐let‐7a‐5p and relieve suppression for IL‐13/IL‐6 in CD4 + T cells. Conclusions and clinical relevance Our data suggest that hsa_circ_0005519 may induce IL‐13 and IL‐6 expression by regulating hsa‐let‐7a‐5p in CD4 + T cells ...
hsa‐let‐7a‐5pPBMCsBackground Circular RNAs (circRNAs) are a class of nonヽoding RNAs that could serve as novel biomarkers for the diagnosis and treatment of diseases. We hypothesized that circRNAs of CD4 T cells are involved in asthma. Objective In this study, we investigated the circRNA...
Moreover, hsa-let-7a and MIR-145 co-transfection significantly increased apoptosis induction compared to separate transfected cells and control through modulating the expression levels of apoptosis-related genes including Bax , Bcl-2 , P53 , Caspase-3 , Caspase-8 , and Casp...