Our results work in concert with these observations to reflect a high global genomic instability in IDC-P through HRD score calculation. Therefore, patients with IDC-P should be recommended to perform HRD score tests. Also, all samples used in this study were collected at the time of their ...
Our results urge the necessity of harmonisation on bioinformatics pipeline during HRD score calculation.SequenzaPureCN (tumor-only)Positive Percentage Agreement100%96.1%Negative Percentage Agreement50.4%83.2%Overall Percentage Agreement69.2%88.2%Xiaopei Chao...
(HRD+/HRD- defined by HRD threshold of 42) is not statistically significant (Fisher's exact test p value = 0.1998, odds ratio=3.5), likely due to small cohort sizes.These results suggest that combination of CNVkit and scarHRD for HRD score calculation may be an alternative approach for ...
One of the conventional approaches to HRD prognostication has generally centered on identifying deleterious mutations within the BRCA1/2 genes, along with quantifying the genomic scars, such as Genomic Instability Score (GIS) estimation with scarHRD. However, the scarHRD method has limitations in ...