We additionally analyzed anticancer drug response in cell line-derived xenograft models using the dataset of ROADMAPS (Responses to Oncology Agents and Dosing in Models to Aid Preclinical Studies).Results: A total of 1260 cell lines from the CCLE were analyzed. HRD score and SBS3 were positively...
each permuted dataset (n= 3 per permutation rate).hExample of a FACS=S PERT=G1/2 GM18507 cell. Bins are colored by HMMcopy (top) and PERT replication (bottom) states. Arrows point to cell-specific CNAs. Title includes quality score and S-phase probability from Laks et al. classifiers....
each permuted dataset (n= 3 per permutation rate).hExample of a FACS=S PERT=G1/2 GM18507 cell. Bins are colored by HMMcopy (top) and PERT replication (bottom) states. Arrows point to cell-specific CNAs. Title includes quality score and S-phase probability from Laks et al. classifiers....
et al. Evolution of circulating tumor DNA profile from first-line to subsequent therapy in metastatic renal cell carcinoma. Eur. Urol. 72, 557–564 (2017). CAS PubMed Google Scholar Oxnard, G. R. et al. Noninvasive detection of response and resistance in EGFR-mutant lung cancer using ...
S1A, S100A16+/− mice presented a significantly decreased pathologic score on the tubular injury compared with WT mice after IRI induction. These data were consistent with our previous studies [7]. The expressions of S100A16 and HRD1 detected by western blots were significantly increased in ...
(as denoted in Fig.3a), for a specific patient and time point. The color intensity signifies the normalized enrichment score (NES) results of enrichment analysis obtained by using all the edgeR differentially expressed genes for that comparison at FDR < 0.01 and |log2 fold change|> =...
KEYTRUDA, as a single agent, is indicated for the first-line treatment of patients with metastatic or with unresectable, recurrent HNSCC whose tumors express PD-L1 [Combined Positive Score (CPS) ≥1] as determined...
cancer-testis antigens (CTA) score, intratumor heterogeneity (ITH), fraction altered, number of segments, number of segments with loss of heterozygosity (LOH) events (LOH_n_sig), bases fraction with LOH events (LOH_frac_altered), homologous recombination defects (HRD), and aneuploidy score (...
(Fig.1b; Supplementary information, Fig.S2d). As an example, HNRNPM is known to preferentially bind poly-U sites with single-stranded structure.34Indeed, the ratio of single- (icSHAPE score > 0.8) vs double-stranded (icSHAPE score < 0.2) regions for HNRNPM was 3.1:1 in HepG...
L. et al. Homologous Recombination Deficiency (HRD) Score Predicts Response to Platinum-Containing Neoadjuvant Chemotherapy in Patients with Triple Negative Breast Cancer. Clin Cancer Res 22, 3764–3773 (2016). 26. Li, Q. et al. A phase II study of capecitabine plus cisplatin in metastatic ...