High risk HPV primary screening is replacing organised cytology‐based screening based on increased sensitivity to detect high grade intra〆pithelial neoplasia and the very high negative predictive value which will allow extended screening intervals. The benefit of increased CIN detection and cancer ...
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By using this approach we have biased our initial screen to detect even very low copy number HPV DNA. Samples which were positive for HPV DNA by nested PCR underwent massively parallel deep sequencing, followed by bioinformatic analysis to determine whether any viral transcripts (HPV or otherwise)...
Controversy remains over whether high-risk human papillomavirus (HPV) DNA testing should be used as a primary screen for cervical cancer. The aims of our s... Fang-Hui Zhao MD a *,Margaret Jane Lin BS b *,Feng Chen BSc a,... - 《Lancet Oncology》 被引量: 315发表: 2010年 Comparison...
While "high risk" (oncogenic) virus types are responsible for 99.7% of all cervical cancer, most infections do not lead to cervical cancer. Liquid-based cytology (e.g., ThinPrep®) and conventional Pap smears are both acceptable for cervical cancer cytology. ...
For primary HPV screening, all HPV positive results need additional triage, but the management of HPV positive women with negative cytology is particularly challenging, since the risk in this group is too high to return women to regular screening, but too low for colposcopy referral [15], [24...
Host-cell DNA methylation analysis can be used to triage women with high-risk human papillomavirus (HPV)-positive self-collected cervicovaginal samples, but current data are restricted to under-/never-screened women and referral populations. This study evaluated triage performance in women who were ...
In Japan, recommendations for HPV vaccines were suspended in 2013 due to unfounded safety fears. Although vaccine opponents claim modifying sexual behavior can prevent cervical cancer, no comprehensive data exist on sexual behavior and the risk of high-g
This systematic review reveals high prevalence of multiple high-risk HPV genotypes among HIV-positive individuals, highlighting the impact of HPV/HIV co-infection on cervical cancer development. Low CD4 counts ranging from severe to moderate immunosuppression were found to associated with increased persist...
Zhao, Y. et al. Real-world effectiveness of primary screening with high-risk human papillomavirus testing in the cervical cancer screening programme in China: a nationwide, population-based study.BMC Med.19, 164 (2021). Article Kaljouw, S. et al. Reducing unnecessary referrals for colposcopy ...