In this chapter, we provide an overview of the hypothalamus–pituitary–adrenal (HPA) axis, and how stress, dysregulation of stress hormones and HPA axis dysfunction are currently thought to play a role in AD pathogenesis.YashB.JoshiDomenicoPraticò...
Stress and HPA Axis Dysfunction in Alzheimer’s Disease. In: Pratico D, Meccoci P, editors. Studies on Alzheimer’s Disease. New York: Springer; 2013. pp. 159–65.Joshi YB, Pratico D. Stress and HPA Axis Dysfunction in Alzheimer's Disease. In: Pratico D, Meccoci P, editors. ...
Simultaneously, despite its sensitivity to stress, the developing microbiome contributes to long-term health. Following stress exposure, HPA-axis activation regulates the “fight or flight” response with the release of glucose and cortisol. Here, we investigated the interaction between the oral ...
Stress responses are controlled by the hypothalamus pituitary adrenal (HPA)-axis and maladaptive stress responses are associated with the onset and maintenance of stress-related disorders such as major depressive disorder (MDD). Genes that play a role in the HPA-axis regulation may likely contribute...
OBJECTIVE: Fatigue is one of the most common and distressing symptoms experienced by cancer patients and survivors. However, the etiology of cancer-related... JE Bower,PA Ganz,N Aziz - 《Psychosomatic Medicine》 被引量: 302发表: 2005年 Suppression of the HPA Axis Stress-Response: Implications ...
The link between childhood trauma and depression: insights from HPA axis studies in humans. Childhood trauma is a potent risk factor for developing depression in adulthood, particularly in response to additional stress. We here summarize results f... C Heim,DJ Newport,T Mletzko,... - 《...
What is the HPA axis and what does it do? The main function generally attributed to the HPA axis involves the body's reaction to stress. When something stressful happens to us, our initial response is mediated by thesympathetic nervous system. This response occurs almost immediately, and result...
Stress generally induces an imbalance in homeostasis; but, if the stress is prolonged, its cumulative effects can result in changes that negatively affect tissues and organ systems (allostatic overload). Effects of stress on the HPA-axis and its regulation through the hippocampus serves as a ...
HPA轴与神经学及心理学所涉及的情绪紊乱(mood disorders)和官能性疾病都有一定关系,比如焦虑症(anxiety disorder), 躁郁症(bipolar disorder), 失眠(insomnia), 创伤后心理压力紧张综合征(post-traumatic stress disorder), 注意力不足过动症(ADHD), 抑郁症(major depressive disorder), 倦怠(burnout), 慢性疲劳...
HPA axis - short for hypothalamic-pituitary-adrenal axis. The HPA axis is a term used to represent the interaction between the hypothalamus, pituitary gland, and adrenal glands; it plays an important role in the stress response.