HPA axis reactivityChronic psychosocial stress is increasingly being recognised as a risk factor for sporadic Alzheimer's disease (AD). The hypothalamic-pituitary-adrenal axis (HPA axis) is the major stress response pathway in the body and tightly regulates the production of cortisol, a ...
Journal of Family and Reproductive Health 2009 ;3: 101-108.Zangeneh FZ, Shooshtary FS. Chronic Stress and Limbic-Hypothalamopituitary-Adrenal Axis (LHPA) Response in Female Reproductive system. J Fam Reprod Health 2009; 3: 101-108.Zangeneh FZ, Shooshtary FS. Chronic stress and limbic-...
Chronic stress activates the sympathetic nervous system (SNS) and hypothalamic–pituitary–adrenal (HPA) axis to aggravates tumorigenesis and development. Although the importance of SNS and HPA in maintaining homeostasis has already attracted much attention, there is still a lot remained unknown about th...
A review of human and animal epidemiological studies found that long-term stress and genetic factors may act through the hypothalamic-pituitary-adrenal (HPA) axis a pathway in the brain that mediates stress responses to contribute to the development ofAlzheimer's disease. The researchers also propose...
HPA-axis functionality Chronic stress and HPA-axis functionality have been associated with the maintenance of AUD (e.g., reinstatement drug seeking, withdrawal) [149]. Two studies investigated corticotropin-release factor (CRF) expression in rats [116,150]. One study observed age-related differences...
Acute alcohol intake causes a stress-like response that includes a transient increase in plasma cortisol30. In contrast, chronic alcohol use leads to dysregulation of the HPA axis and a sustained elevation of plasma cortisol30. Cortisol causes multiple cellular effects in different tissues by binding...
Objective 1: To test whether CaF in older adults are positively related with altered stress system activity, specifically overactivity of the sympathetic nervous system (SNS) and hypoactivity of the hypothalamus–pituitary–adrenal (HPA) axis, and higher levels of systemic low-grade inflammation. It...
The HPA Axis (Hypothalamus Pituitary Adrenal Axis) is affected by both internal physiological stressors (cytokines, hypoxia, macromolecules etc) and by external stressors (source of anxiety, fear etc.) which threaten the organisms homeostasis. Cortisol binds to cortisol receptors throughout the body....
Chronic stress activates ADRBs, the PKA/VDCC/IGF axis and AMPK signaling pathways to promote cancer cell proliferation. Chronic stress leads to cancer chromosomal instability and DNA damage through activation of Gs-PKA/β-arrestin and suppression of p53. Furthermore, chronic stress promotes ...
An increasing number of studies indicate that adrenergic signalling plays a fundamental role in chronic stress-induced tumour progression and metastasis. However, its function in gastric cancer (GC) and its potential mechanisms remain unknown. The expres