The cellular environment is critical to protein function. How is information from many cellular components decoded in order to fine-tune biological activity? New models of biomolecular recognition raise the possibility that proteins engage in specific, yet fuzzy, interactions with their functional partners...
For example, introducing synonymous mutations into the Chloramphenicol acetyltransferase (CATIII) enzyme decreased its specific activity by 20%4. Since the specific activity is an ensemble average over the soluble fraction of proteins, it can be inferred that these synonymous mutations caused a portion ...
Protein-protein interactions (PPIs) play vital roles in life and provide new opportunities for therapeutic interventions. In this large data analysis, 3,300 inhibitors of PPIs (iPPIs) were compared to 17 reference datasets of collectively ~566,000 compounds (including natural compounds, existing drug...
The findings give scientists a better understanding of the basic biology of T cells and pave the way toward new therapies for the multitude of diseases in which T cell function is centrally involved. "This new understanding of how to control rest and activation in T cells could eventually have...
This method presents a precision, recall, and F1 score of 0.72, 0.81, and 0.76 for the training set and 0.91, 0.73, and 0.81 for an independent test set. Proteins 2014; 82:479–490. 2013 Wiley Periodicals, Inc. 展开 关键词: Proteins Molecular Dynamics Simulation Computational Biology ...
to both the plastid and ES. Our analyses show that these proteins all are of eukaryotic rather than cyanobacterial origin, and that their non-plastid homologs are equipped with signal peptides responsible for co-translational import into the host ES. Our results indicate that vesicular trafficking ...
Furthermore, both the proteins and snoRNAs are involved in ribosome biogenesis, suggesting that the expression of the protein-coding genes and noncoding ... LC Shen,BN Weinstein,SW Roy,... - 《Molecular Biology & Evolution》 被引量: 0发表: 2021年 Characterization of miRNAs in Cultured Atlant...
It is suggested that only these patients be subjected to aggressive local therapy. The effects of no treatment, ortho- and megavoltage radiotherapy, surgery and combinations of surgery and radiotherapy are reviewed. The need for cooperative randomized clinical trials to test the biological hypothesis ...
Motility assays and microscopy studies reveal that Streptomyces spores are transported to plant tissues by interacting directly with the flagella of both gram-positive and gram-negative bacteria. Genetics experiments demonstrate that this form of motility is facilitated by structural proteins on the spore...
A family of proteins that contain a BAR (Bin, amphiphysin, Rvs) domain with extra amphipathic helices. Endophilin-1 binds to and tubulates lipid membranes. Spheroid A geometric shape that is similar to a sphere but that is not exactly spherical (for example, a mis-shaped ball). ...