Article Open access 04 May 2021 MVsim is a toolset for quantifying and designing multivalent interactions Article Open access 06 September 2022 A bead-based method for high-throughput mapping of the sequence- and force-dependence of T cell activation Article 05 September 2022 Introduction...
To test this CS model, we first used NMR RD to measure the isomerization kinetics in a ssRNA containing the most abundant m6A consensus sequence1,2in eukaryotic mRNAs (\({{{\mathrm{ssGGACU}}}^{{{\mathrm{m}}}^6{{{\mathrm{A}}}\); Fig.2b). This was important given that prior kine...
SEQRES - sequences of peptide chains; ATOM - coordinates of the atoms that are part of the protein; HETATM - coordinates of hetero-atoms. Related extensions: PDB files can also be saved asENTorBRK. Legacy: PDB is now considered a legacy format, being replaced by the newer mmCIF (extension...
(i)≥20 distinct and independent MD simulations to autonomously fold a fast-folding protein sequence using FF12MC, which results in ≥20 sets of instantaneous protein conformations in time, (ii) a cluster analysis of all instantaneous conformations from the ≥20 sets to obtain the average ...
To investigate how 10C9 was matured, we compared the rearranged sequence of 10C9 with that of the corresponding germ line gene (supplemental Fig. 3). There are seven (H-Gln3, H-Asn34, H-Arg54, H-Thr56, H-Thr61, H-Ser73, and H-Cys94) and eight mutated residues (L-Glu1, L-...
Structural and Sequence Similarity Makes a Significant Impact on Machine-Learning-Based Scoring Functions for Protein-Ligand Interactions. J. Chem. Inf. Model. 2017, 57, 1007–1012. [Google Scholar] [CrossRef] [PubMed] Su, M.; Feng, G.; Liu, Z.; Li, Y.; Wang, R. Tapping on the ...
(≥4.13 Å)). The average class was assumed to be an allowance to emphasize the differences between the excellent and poor classes. TM-score [21] is a sequence-length-independent measure of structural similarity; however, there are short ProSs whose sequence length is 11 at most. Because ...
As a rule, a user's password is not stored in the .psw file in plaintext. Instead, the .psw file contains the password's hash, a calculated byte sequence, uniquely tied to the password. It is impossible to restore a password from its hash, however, it is possible to run a brute-...
Parsing the genomic sequence of cyanophage S-2L (AX955019) in the search for a protein involved in DNA replication, we identified one ORF corresponding to a member of the Archaeo-Eukaryotic Primase (AEP) superfamily, which had not been noted earlier. We will refer to it as “PrimPol”, ...
T. Sortase A as a novel molecular 'stapler' for sequence-specific protein conjugation. Bioconjug. Chem. 18, 469–476 (2007). 9. Goldenberg, D. P. & Creighton, T. E. Circular and circularly permuted forms of bovine pancreatic trypsin inhibitor. J. Mol. Biol. 165, 407–413 (1983). ...