The TCR integrates forces in its triggering process upon interaction with pMHC. Force elicits TCR catch-slip bonds with strong pMHCs but slip-only bonds with weak pMHCs. We develop two models and apply them to analyze 55 datasets, demonstrating the models’ ability to quantitatively integrate and...
in both small interfering RNA(siRNA) and miRNA-mediated silencing, is nucleotides 2 to 7/8 (as measured from the 5' end) [18]. This region, known as the seed sequence [23], provides the specificity in target selection, and a greater portion of the target binding energy...
Parsing the genomic sequence of cyanophage S-2L (AX955019) in the search for a protein involved in DNA replication, we identified one ORF corresponding to a member of the Archaeo-Eukaryotic Primase (AEP) superfamily, which had not been noted earlier. We will refer to it as “PrimPol”, ...
A major reason has been attributed to the diversity of sequences and structures of AMPs, thus raising the possibility that they act in diverse ways [8], [9], including through formation of pores and carpets [4], [7], [10], [11], [12]. Pore formation occurs as a result of the ...
To investigate how 10C9 was matured, we compared the rearranged sequence of 10C9 with that of the corresponding germ line gene (supplemental Fig. 3). There are seven (H-Gln3, H-Asn34, H-Arg54, H-Thr56, H-Thr61, H-Ser73, and H-Cys94) and eight mutated residues (L-Glu1, L-...
SEQRES - sequences of peptide chains; ATOM - coordinates of the atoms that are part of the protein; HETATM - coordinates of hetero-atoms. Related extensions: PDB files can also be saved as ENT or BRK. Legacy: PDB is now considered a legacy format, being replaced by the newer mmCIF (ex...
Whether specific sequences in the viral RNA, or other viral proteins render SARS CoV mRNA resistant to RNA cleavage is yet to be investigated. HSV-1 VHS RNase selectively degrades stable cellular mRNAs and immediate early viral RNAs, but stabilizes host stress response mRNAs and viral late ...
The average class was assumed to be an allowance to emphasize the differences between the excellent and poor classes. TM-score [21] is a sequence-length-independent measure of structural similarity; however, there are short ProSs whose sequence length is 11 at most. Because TM-scores for these...
As a rule, a user's password is not stored in the .psw file in plaintext. Instead, the .psw file contains the password's hash, a calculated byte sequence, uniquely tied to the password. It is impossible to restore a password from its hash, however, it is possible to run a brute-...
Our findings represent valuable knowledge about antibiotic capture as an important resistance mechanism and how to possibly circumvent it in the case of albicidin. Results AlbA is a MerR-like transcriptional regulator A sequence similarity search using Basic Local Alignment Search Tool (BLAST) for ...