Localization can be used to bring proteins together or to separate them. For example, we found an extremely rare mutation in the gene that codes for a secreted protein, the luteinising hormone beta (LHB), in a patient. To prove that the wildtype (WT) and mutant proteins were...
Among the physicochemical cues in the cellular microenvironment that orchestrate cell processes, the different levels of curvature in the extracellular matrix and intrinsic to the tissues play a pivotal role in the spatiotemporal control of key cellular functions. Curvature influences multicellular organizati...
A vital function of the immune system is to detect alterations in tissue homeostasis and respond in a context-dependent manner. To achieve this, immune and stromal cells, particularly those located at barrier sites, express a diverse range of germline-encoded receptors termed pattern recognition rece...
Schematically, cellular vesicles have an extracellular, luminal or cytoplasmic content and come in two flavors. First, protein-coated vesicles, such as clathrin-coated endocytotic vesicles [1], COPI-coated or COPII-coated vesicles that bud off Golgi and ER membranes, respectively [2, 3] or ...
However, cells must control the natural tendency of proteins and nucleic acids to phase separate to build functional condensates at the correct time and location. The cellular mechanisms that regulate phase separation thus are a critical part of understanding how cells use biomolecular condensation to ...
It is commonly assumed that a heterotrophic ancestor of the supergroup Archaeplastida/Plantae engulfed a cyanobacterium that was transformed into a primary plastid; however, it is still unclear how nuclear-encoded proteins initially were imported into the new organelle. Most proteins targeted to primar...
It is commonly assumed that a heterotrophic ancestor of the supergroup Archaeplastida/Plantae engulfed a cyanobacterium that was transformed into a primary plastid; however, it is still unclear how nuclear-encoded proteins initially were imported into the new organelle. Most proteins targeted to primar...
Assessment of the impact of variation in chloroplast and mitochondrial DNA (collectively termed the plasmotype) on plant phenotypes is challenging due to the difficulty in separating their effect from nuclear-derived variation (the nucleotype). Haploid-inducer lines can be used as efficient plasmotype...
International Journal of Molecular Sciences Review Relax, Cool Down and Scaffold: How to Restore Surface Expression of Folding-Deficient Mutant GPCRs and SLC6 Transporters H.M. Mazhar Asjad, Shahrooz Nasrollahi-Shirazi, Sonja Sucic ID , Michael Freissmuth * and Christian Nanoff Institute of ...
Ticks rely heavily on chemosensation to identify and locate hosts. Chemosensation is the main function ascribed to the Haller's organ, a unique structure found on the foretarsus of the first pair of legs. The Haller's organ is not found in any other animals. In addition to detecting host...