Indeed, the first MDS mouse model available supports this concept: Slape and colleagues116 recently showed that BCL-2 overexpression in NHD13 mice corrects macrocytic anemia and delays leukemic transformation. Further mouse models will be required to elucidate the role of apoptosis susceptibility or ...
Indeed, the first MDS mouse model available supports this concept: Slape and colleagues116 recently showed that BCL-2 overexpression in NHD13 mice corrects macrocytic anemia and delays leukemic transformation. Further mouse models will be required to elucidate the role of apoptosis susceptibility or ...
In the fourth and last stage of B12 deficiency, clinical manifestations are experienced by the individual — including macrocytic anemia (a form of anemia in which red blood cells are larger than usual, hence the term “macro”) and, if left untreated, irreversible neurological damage. The more...
Stem cells are endowed with the awesome power of self-renewal and multi-lineage differentiation that allows them to be major contributors to tissue homeostasis. Owing to their longevity and self-renewal capacity, they are also faced with a higher risk of genomic damage compared to differentiated ce...