Evolution of antimicrobial peptides (AMPs) has been shown to be driven by recurrent duplications and balancing/positive selection in response to new or altered bacterial pathogens. We useAlvinella pompejana, the most eurythermal animal known on Earth, to decipher the selection patterns acting on AMP...
and the shorter C-terminal thiopeptide drug-binding domain (TipAS)27. Drug binding to TipAL leads to an upregulation of its own expression and confers resistance against several thiopeptide antibiotics, e.g., thiostrepton, nosiheptide, and promothiocin A16. Previously, ...
For the treatment ofM. hyorhinisandM. hyosynoviaearthritis, antibiotics with the lowest MIC need to be used. MICs indicate the lowest antibiotic concentration which inhibits the growth of Mycoplasma spp. and other bacteria species. The selection of the best antibiotic is ideally based on pharmacokine...
Gut dysbiosis occurs when the balance of bacteria in the gut becomes imbalanced because there is not the ideal number of good or bad bacteria or a combination of the two. It can happen for a variety of reasons, including due to diet, stress, antibiotic use, or as a result of illnesses....
A. niger could thus become an essential companion of astronauts for the autonomous production of food, enzymes and antibiotics during space travel. What needs to be done to achieve these visionary goals? In this chapter, we will discuss the opportunities of A. niger as a cell factory spanning...
J. A common mechanism of cellular death induced by bactericidal antibiotics. Cell 130, 797–810 (2007). Article CAS PubMed Google Scholar Wang, X., Zhao, X., Malik, M. & Drlica, K. Contribution of reactive oxygen species to pathways of quinolone-mediated bacterial cell death. J. ...
The COS-7 cells were cultured in DMEM (Gibco, USA) containing 10% FBS (Gibco, USA) and antibiotics (100 units mL−1penicillin and 100 µg mL−1streptomycin) in a 5% CO2humidity incubator at 37 °C. The cells were subcultured every two or three days. ...
A clear limitation of the current study is that we did not obtain minimum inhibitory concentrations (MICs) to quantify the isolates’ susceptibility towards antibiotics. Only MICs allow for a quantitative comparison of susceptibility. Moreover, the lack of species- and infection-specific breakpoints in...
The concept aims at controlling antimicrobial use, decreasing the number of AMR bacterial strains and, importantly, reducing the unnecessary use of broad-spectrum antibiotics [8]. In collaboration with ICDs, the AST plays a major role in managing antimicrobial use to control infectious diseases due ...
3.1.10. When Could GPs Give Antibiotics to COVID-19 Patients at Home? Since the beginning of the COVID-19 epidemic, antibiotics with immunomodulatory properties, such as azythromicin, have been proposed for the early treatment of this infection. However, antibiotic therapy for the treatment of...