Hypertension places extreme stress on blood vessels, causing them to narrow and stiffen. When the blood vessels of the kidneys are affected, they are less able to remove excess water from your blood. This, in turn, increases the volume of water in your blood vessels, further raising your blo...
YERVOY® (ipilimumab) as a first treatment for adults with a type of advanced stage lung cancer (called non-small cell lung cancer) when your lung cancer has spread to other parts of your body (metastatic) and your tumors are positive for PD-L1, but do not have an abnormal EGFR or ...
Angiotensin II is the active molecule which binds to the AT1 receptor, leading to downstream effects such as vasoconstriction, aldosterone secretion, and sodium retention. In the heart, AT1 activation leads to cellular hypertrophy that results in fibrosis, which ultimately contributes to ventricular ...
The best of National Geographic delivered to your inbox Sign up for more inspiring photos, stories, and special offers from National Geographic.Sign Up Legal Terms of Use Privacy Policy Interest-Based Ads Our Sites Nat Geo Home Attend a Live Event Book a Trip Buy Maps Inspire Your Kids Shop...
G. et al. EGFR interacts with the fusion protein of respiratory syncytial virus strain 2–20 and mediates infection and mucin expression. PLOS Pathog. 12, e1005622 (2016). Article PubMed PubMed Central CAS Google Scholar Tayyari, F. et al. Identification of nucleolin as a cellular ...
For example, in people with metastatic lung cancer to the liver, patients with EGFR-positive tumors had a median survival of 11.7 months, while patients with EGFR-negative tumors had a median survival of only 4.1 months.5 The presence of liver metastases has also been linked to a poorer prog...
the biochemistry of EGFR-EGFR interactions is still being worked out by multiple labs after more than 30 years of intensive study. For instance, it is not proven how extracellular dimerization results in kinase-domain dimerization, or how the C-terminal tail (which is intrinsically denatured)...
However, given the prominence of PI3K signalling in cancer and the crucial role of this pathway in linking cancer growth with metabolism, these clinical results could arguably be improved upon. In this Review, we discuss past and present efforts to overcome the somewhat limited clinical efficacy ...
Overall survival has steadily moved from being the primary to a secondary endpoint. However, it is still of interest with papers presenting overall survival results with the caveat of subsequent treatments, but little or no investigation into their effect. This review shows that there is a methodol...
The results also show that the contribution of phenotypic screening to the discovery of first-in-class small-molecule drugs exceeded that of target-based approaches — with 28 and 17 of these drugs coming from the two approaches, respectively — in an era in which the major focus was on ...