G. et al. EGFR interacts with the fusion protein of respiratory syncytial virus strain 2–20 and mediates infection and mucin expression. PLOS Pathog. 12, e1005622 (2016). Article PubMed PubMed Central CAS Google Scholar Tayyari, F. et al. Identification of nucleolin as a cellular ...
However, given the prominence of PI3K signalling in cancer and the crucial role of this pathway in linking cancer growth with metabolism, these clinical results could arguably be improved upon. In this Review, we discuss past and present efforts to overcome the somewhat limited clinical efficacy ...
I want there to be a great future for those of us who (like myself) want to become posthumans. I want to encourage all humans to explore enhancing their health, intelligence and productivity. There is a real risk of being left behind if you do not do that. I also want all of human...
Angiotensin II is the active molecule which binds to the AT1 receptor, leading to downstream effects such as vasoconstriction, aldosterone secretion, and sodium retention. In the heart, AT1 activation leads to cellular hypertrophy that results in fibrosis, which ultimately contributes to ventricular ...
The five stages are based on eGFR test results measured in milliliters per minute (mL/min):32 Stage 1: Normal kidney function (eGFR over 90 mL/min) Stage 2: Mild CKD (eGFR 60-89 mL/min) Stage 3: Moderate CKD (eGFR 30-59 mL/min) ...
YERVOY® (ipilimumab) as a first treatment for adults with a type of advanced stage lung cancer (called non-small cell lung cancer) when your lung cancer has spread to other parts of your body (metastatic) and your tumors are positive for PD-L1, but do not have an abnormal EGFR or ...
Read More Exploring HIFU in Early to Intermediate Prostate Cancer Treatment Jordyn Sava April 22nd 2025 Article Alexander Kenigsberg, MD, discusses a new nonsurgical, robotic-focused ultrasound procedure for prostate cancer. Read More Leighl Covers PALOMA-3 Trial of SC Amivantamab in NSCLC ...
How do you feel about these polling results? Nobody would go for abiraterone. I am pleased to see that, really, because we have now established that moving from one agent to the other that is targeting the same mechanism of action may not be the prudent way to go, especially for thos...
Glioblastoma multiforme influence on the elemental homeostasis of the distant organs: the results of inter-comparison study carried out with TXRF method 2024, Scientific Reports A Phyto-mycotherapeutic Supplement, Namely Ganostile, as Effective Adjuvant in Brain Cancer Management: An In Vitro Study Usin...
Moreover, Nivolumab plus ipili- mumab in first-line NSCLC patients had longer overall survival (OS) compared to chemotherapy and was not associated with PD-L1 expression levels [5]. In addition, in EGFR/ALK-altered NSCLC, there was no difference in survival between patients with tumor PD-L1...