In addition to fetching phenotypic data, we will investigate how to work with different sources and types of phenotypic data. The goal is to retrieve phenotypic annotations that we will use to perform GWAS (notebookG203) and PRS (notebookG205) studies of hypertension. We will use four ...
With the intensification of the greenhouse effect, a series of natural phenomena, such as global warming, are gradually recognized; when the ambient temperature increases to the extent that it causes heat stress in plants, agricultural production will in
Use a Punnett square to predict the offspring in a cross between a dwarf pea plant (homozygous recessive) and a tall pea plant (heterozygous). What is the phenotypic ratio of the offspring? What is a monohybrid cross? What is GWAS in genetics? How does it work? Consider this cross: BB...
Terminal branches of each vessel distribute blood to the hepatic sinusoids; these low-pressure, slow-flowing channels supply blood to the repetitive functional units of the liver, the hepatocytes, enabling them to perform their metabolic functions and to degrade toxic blood constituents. The hepatic ...
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which has been proven to regulate rice heat tolerance, is accurately spliced downstream ofONAC023-OsFKBP20-1b/OsSF3B1to perform its biological functions normally (Chang et al.2024). The deletion of the membrane-associated NAC transcription factorOsNTL3makes rice heat sensitive because it migrates...
(Gusareva and Van Steen2014). Far too often, GWAI analysis procedures related to data cleansing/quality control (QC), missing observations, population structure control, effect encoding, and multiple testing are simply taken over from the GWAS scene. However, too little SNP variation will hamper ...
For the physical traits, we were only able to perform the second step of the MR analysis (i.e., the effect of the trait on breast cancer) since we did not have access to the full GWAS summary data. There was limited evidence of an effect from breast size on breast cancer risk (OR...
“Teacher,” they said, “we want to see you perform a miracle.” 39“How evil and godless are the people of this day!” Jesus exclaimed. “You ask me for a miracle? No! The only miracle you will be given is the miracle of the prophet Jonah. 40In the same way that Jonah spent...
The first approach may be more effective and rigorous, yet the second approach may be easier for non-specialists to understand and interpret. GWAS, genome-wide association study; HGMD, Human Gene Mutation Database; I, indel; LSDB, locus-specific database; NS, non-synonymous; OMIM, Online ...