But in order to make the project a success, the right technology was needed. “At that point in time, it became obvious to me that we needed to engage other partners in developing plates for those systems. And that'...
Recently aprepitant has shown promise in mouse xenograft studies of colon, lung and pancreatic cancer and melanoma. Since aprepitant was thought to trigger release of calcium stored in the lumen of the endoplasmic reticulum, the step that we showed triggers hyperactivation of the a-UPR by ErSO ...
and ductal cells, which form the network of tiny ducts delivering bile to the intestine. These work in conjunction with other supporting cells, like the blood vessels or the mesenchymal cells. For building liver organoids, in the beginning the researchers only used ductal ...
To help with these studies, Yilmaz’s lab has developed a way to use mouse or human intestinal stem cells to generate miniature intestines or colons in cell culture. These “organoids” can then be exposed to different nutrients in a very controlled setting, allowing researchers to analyze how...
"By screening ten different type of cells and organoids, we found that lung, colon, heart, liver, and pancreatic organoids and dopamine neurons can be infected by SARS-CoV-2," says Dr. Chen. "This work presented the first stem cell model to understand the which organs and cells within ...
This affords better defined and more reproducible mucin substrates (e.g. mucin produced by intestinal organoids and sophisticated analytical methods; see below). 5. Novel methods, models and technologies to investigate the GI mucus, glyco-code, and bacterial interaction 5.1. Chemical and biophysical...
This approach may even elucidate the nature and evolution of consciousness as a manifestation of the cellular continuum from unicellular to multicellular life. We need such a functional genomic mechanism for the process of evolution if we are to make progress in biology and medicine." John S. ...
This approach may even elucidate the nature and evolution of consciousness as a manifestation of the cellular continuum from unicellular to multicellular life. We need such a functional genomic mechanism for the process of evolution if we are to make progress in biology and medicine.” John S. ...