Concerning cognitive decline, despite poor positive results of PUFA dietary supplementation in Alzheimer’s disease (AD) patients, RCTs using DHA supplementation in subjects carrying the apolipoprotein E ε4 (APOE4) allele, a risk factor for AD, reveal an improvement of pre-dementia.64 Overall, ...
NLRP3 activation has also been suggested to be driven by mtROS, which are generated by complex III and, to a lesser extent, complex I of the ETC in the mitochondria, and the levels of mtROS can increase in response to cellular stress or ETC perturbation [35]. The NLRP3 activators ATP ...
Lp(a)consists of an LDL-like core lipoprotein molecule but differs from other lipoproteins as it contains a unique apolipoprotein(a) or apo(a)(2). Similar to LDL, an Lp(a) particle also contains one molecule ofapolipoprotein B (apoB). Lipoproteins that promote atherosclerosis (the leading u...
HDL is actually more complex than we once thought. Rather than being a single kind of particle, HDL is is now considered a family of different particles. All HDL contains lipids (fats), cholesterol and proteins (called apolipoproteins), but some types of HDL are spherical while others are ...
"A systematic review and meta-analysis of randomized controlled trials of the effect of konjac glucomannan, a viscous soluble fiber, on LDL cholesterol and the new lipid targets non-HDL cholesterol and apolipoprotein B." Am J Clin Nutr. May 2017. https://pubmed.ncbi.nlm.nih.gov/28356275/ ...
reuteri NCIMB 30242 per day for nine weeks reduced LDL-cholesterol levels, as well as hs-CRP, apolipoprotein B-100 (apoB-100) (a lipid fraction associated with atherosclerosis development), and fibrinogen levels, and increased vitamin D levels.158,159 Similarly, a yogurt providing 1.4 billion ...
added to maximally tolerated statin therapy in patients at high risk for CVD significantly reduced LDL-C by 36% at week 12 compared with 17% for bempedoic acid alone or 23% for ezetimibe alone; similar results were observed with non–HDL-C, total cholesterol and apolipoprotein B (ApoB) [...
Niacin favorably affects apolipoprotein (apo) B... Vaijinath S. Kamanna PhD,Moti L. Kashyap MD - 《American Journal of Cardiology》 被引量: 666发表: 2008年 Reduced digestibility of beef tallow and cocoa butter affects bile acid excretion and reduces hepatic esterified cholesterol in rats. We...
Alzheimer's disease is known to be associated with variation in the apolipoprotein E gene (APOE). The therapeutic response in AD is genotype-specific, with APOE*4/4 carriers representing the worst responders to conventional treatments,114 such as donepezil, rivastig- mine, galantamine, and ...
Apolipoprotein B-gene DNA polymor- phisms associated with myocardial infarction. N Engl J Med 1986;315:1509 –1515. 20. Poduslo SE, Neal M, Herring K, Shelly J. The apolipoprotein CI A allele as a risk factor for Alzheimer's disease. Neurochem Res 1998;23:361–367. 21. Corder EH, ...