Current guidelines recommend a loading dose of 25-30 mg/kg followed by vancomycin dosages of 15-20 mg/kg given every 8-12 hours for patients with normal renal function [54]. Monitoring of trough concentrations is necessary after the forth dose to maintain serum trough concentrations of 15-20...
Current guidelines recommend a loading dose of 25-30 mg/kg followed by vancomycin dosages of 15-20 mg/kg given every 8-12 hours for patients with normal renal function [54]. Monitoring of trough concentrations is necessary after the forth dose to maintain serum trough concentrations of 15-20...
/MIC ratio of ≥400 (see next section on PK/PD indices) [20]. Nevertheless, AUC values greater than 600 mg.h/L are also associated with a higher risk of acute kidney injury, making it nearly impossible to safely and effectively treat microorganisms with vancomycin MICs > 1 mg/L [...