(redirected fromArginine Alpha Ketoglutarate) AcronymDefinition AAKGArginine Alpha Ketoglutarate Copyright 1988-2018AcronymFinder.com, All rights reserved. Suggest new definition Want to thank TFD for its existence?Tell a friend about us, add a link to this page, or visitthe webmaster's page for fr...
The metabolite, alpha-ketoglutarate inhibits non-alcoholic fatty liver disease progression by targeting lipid metabolism Background:Non-alcoholic liver disease is of increased concern and contributing to economic burdens not only in developing countries but in developed count... K Nagaoka,J Mulla,K Cao...
OAT converts L-ornithine to 2-ketoglutarate [49]. FUNG increased oat which could reduce ornithine for polyamine (putrescine, spermidine, and spermine) synthesis via ornithine decarboxylase, having subsequent affects on cell proliferation. DCT (dopachrome tautomerase) and SF3A1/SF3A2 (splicing factors ...
The observation that mtDNA polymorphisms appear to influence the severity of CFS is consistent with observations in other disease areas where such polymorphisms increase the susceptibility to the development of metabolic and neurodegenerative diseases and susceptibility to microbial infection (review (Hendrickso...
(29 ℃), MAN was the major cytoplasmic sugar alcohol, and any changes to pH did not result in changes to lipid composition, provided that temperature was stably maintained. Increased temperature (38 ℃) led to over a twofold increase in the total cytosolic sugar content with concurrent ...
Hydroxylation requires oxygen and α-ketoglutarate, and produces carbon dioxide and succinate. In the absence of oxygen, PHD activity is inhibited, and the HIF-α subunit is no longer degraded; rather it binds to the constitutively expressed HIF-β subunit to form a HIF dimer. HIF dimer then ...
Oxidative stress disturbs cellular ROS homeostasis via a redox relay mechanism [94], which leads to an increase in intracellular ROS levels and modulates key cell signaling pathways. Redox signaling is also crucial in regulating tumorigenesis, autoimmunity, neurodegenerative diseases, and loss of tissue...
In cells treated with TNF and cycloheximide (CHX) under hypoxic conditions, GSDMC was processed by caspase-8 at the D365 residue [168], while in cells treated with α-ketoglutarate, the cleavage occurred at D240 [169]. How the same caspase discriminates where to cleave GSDMC in different ...
Moreover, the high levels of 5hmC in adult neurons (and capacity to further increase), and the specific distribution across cell types and brain regions, indicate an important functional role in addition to preserving cell identity. Recent studies showing that demethylation occurs rapidly after ...