As studies further suggested the HMG-CoA inhibitors could downregulate MDR function, we attempted to improve the efficacy of mitoxantrone and etoposide in patients with relapsed/persistent AML by combining CSA and pravastatin in a single-arm, open-label phase 1/2 trial. Adult patients with ...
More recently, circulating tumor DNA (ctDNA) has gained attention as a new method of MRD assessment [132]. The advent of high-throughput sequencing (HTS)-based approaches has made it possible to detect small amounts of ctDNA that is continually shed into the bloodstream [133]. Preliminary d...
Finally, one must consider bacterial community structures and understand how they modulate their niches, in order to learn how to modulate them into communities, which may ultimately improve patient outcome. Models for Investigating Host–Microbe Interactions Recapitulating complex native physiological ...
Individuals with Hashimoto’s are more susceptible to nutrient deficiencies, particularly that of vitamin B12. Testing for B12 levels can be a proactive way to prevent a deficiency. However, if you do find yourself deficient in vitamin B12, there is something you can do to improve it! I recom...
Acomplete blood count panelmeasures various components of the blood to provide a comprehensive overview of the cells that make it up.Low valuesof red blood cell count, or RBC, hemoglobin, or Hb, and hematocrit, or HCT, would indicate that the patient is suffering from anemia. ...
Streptococcus suis is a zoonotic agent that causes sepsis and meningitis in pigs and humans. S. suis infections are responsible for large economic losses in pig production. The lack of effective vaccines to prevent the disease has promoted the extensive
A New Year’s or New Start Resolution is, of course, an opportunity to strengthen/ improve our health; wellness but also consider one that focuses on helping others with theirs. Some find it’s mucheasier and more rewarding to keep a promise to someone else rather than to themselves. ...
This lower blood pressure makes it easier for theheartto pump blood and can improve the function of a failing heart. In addition, the progression of kidney diseasedue tohigh blood pressureordiabetesis slowed. Why are ACE inhibitors prescribed?
34,35 Efforts to improve the response to the salvage regimens by combining them with novel agents, for example, venetoclax, are ongoing. Venetoclax is an oral, highly selective B-cell leukemia/lymphoma-2 inhibitor with little efficacy as a single agent in AML36; however, it is synergistic ...
Over the last two decades, the understanding of how dysregulated ion channels and transporters are involved in carcinogenesis and tumor growth and progression, including invasiveness and metastasis, has been increasing exponentially. The present review s