PDB structures were used to either apply MD simulation or identify the structural variabilities (end-to-end-/inter- distance of the bound state and the angle between domains) (2C TCR complexed with H2-Kb (PDB codes 2CKB, 1MWA, and 1G6R) and H2-Ldm31 (2E7L), 1G4 TCR complexed with...
a一切的尽头 All terminus[translate] a杰克既会说法语,又会说法语 Jake both can speak French, and can speak French[translate] aHoho wo tsutau ame[translate] aIt takes 45 minutes to get to the city centre from the hotel. 需要45分钟有市中心从旅馆。[translate] ...
1C). The high-resolution map lacks density for the linker between the ß-propeller and N-terminus of the insert helix, further evidence that it is disordered. The higher resolution ARPC2 structure clarifies the sidechain conformations at the C-terminus of ARPC2 and their interactions with ARP...
During the stationary phase, cells switch to a survival mode of metabolism. As growth slows, so too does the synthesis of peptidoglycans, proteins, and nucleic-acids; thus, stationary cultures are less susceptible to antibiotics that disrupt these processes. In bacteria capable of producing endospor...
Substrate unfolding is thought to depend on strong contacts between pore loops and a subset of amino acids in the unstructured sequence directly preceding the folded domain. Here, we identify such contact sequences that promote grip for ClpAP and use ClpA structures to place these sequences ...
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In the context of CE and TS the C-terminus of PAPC has signalling functions which modulates non canonical Wnt-signalling pathways. In a yeast two hybrid screen we have identified proteins which functionally connect PAPC and the Wnt pathways. 展开 ...
FISNA domain. How this transition occurs and how subsequent NLRP3 activation proceeds are open questions. Further studies are also required to decipher the cellular roles of the NLRP3 cage in the context of its localization, identify all the interaction partners, and ascertain the function of PT...
*607642), which maps within the SMS region, is formed by six exons generating an approximately 8.5 Kb mRNA and a 1906 amino-acid protein.6 The RAI1 protein contains a bipartite nuclear localization signal, polyglutamine and polyserine tracts, and a PHD/zinc-finger domain at the C-terminus....
In muscle cells, the continuity between the internal filamentous actin cytoskeleton and the extracellular matrix is ensured by binding of dystrophin at its N-terminus to actin filaments through an actin-binding domain (ABD1) and at its C-terminus, to β-dystroglycan. The latter protein spans the...