These results led to the conclusion that the classification of known epitopes with respect to the experimental conditions used to identify them should be introduced before attempting to characterise epitopic areas in a generic way.doi:10.1016/j.molimm.2010.10.011Virginie Lollier...
We therefore also decided to generate SARS-CoV-2-specific Nbs by using the receptor-binding domain (RBD) as an antigen for immunization. RBD has been shown to be highly immunogenic. This enabled us to identify a large number of Nb candidates, some of which even have strong binding ...
Although we failed to identify antibodies that target a single specific form of α-syn, i.e. monomers, oligomers or fibrils, our results show that it is possible to develop antibodies that target β-sheet rich α-syn oligomers and fibrils or oligomers and fibrils of diverse conformational ...
In this Review, we address the why and how of the immuno-cardiovascular unit, in health and in atherosclerotic disease. We review and discuss fundamental mechanisms that ensure immune tolerance to cardiovascular tissue, and examine how their disruption promotes disease progression. We identify ...
In this Review, we address the why and how of the immuno-cardiovascular unit, in health and in atherosclerotic disease. We review and discuss fundamental mechanisms that ensure immune tolerance to cardiovascular tissue, and examine how their disruption promotes disease progression. We identify ...
Furthermore, the presence of these antibodies correlated very well with disease activity [4]. The diagnostic rele- vance of LAMP-2 ANCA for other rheumatic diseases has yet to be evaluated. In addition to their diagnostic value, LAMP-2 ANCA have also contributed to our understanding of the ...
This complex that differed from the parental virus only in the L234F mutation in F showed the same displacement of the HN head from the F apex as EV2 (Fig. 4G). Escape mutations exact a fitness cost for the virus in human airway To identify fitness consequences of the mutations in the...
Antibodies generally look like the letter Y. On both arms of this Y, they have paratopes, which are regions that selectively bind to certain antigens. They bind to special sites on the antigens called epitopes. Each of the arms of the Y shaped antibody can bind to an individual antigen...
There are two ways to speed it up: Limit the vocab size, i.e., don't load all the ~400k embeddings. Pass the parameter 'max_vocab_size' to the method 'from_text_file' when called. Save the WordEmbeddings model to disc. In follow-up executions, you can load the (binary) model ...
Preclinical strategies that are used to identify potential drug candidates include target-based screening, phenotypic screening, modification of natural substances and biologic-based approaches. To investigate whether some strategies have been more successful than others in the discovery of new drugs, we ...