A survey of tools for variant analysis of next-generation genome sequencing data Recent advances in genome sequencing technologies provide unprecedented opportunities to characterize individual genomic landscapes and identify mutations ... P Stephan,D Andreas,F Maria,... - 《Briefings in Bioinformatics》...
CpG islands (CGIs), clusters of CpG dinucleotides in GC-rich regions, are often located in the 5' end of genes and considered gene markers. Hackenberg et al. (2006) recently developed a new algorithm, CpGcluster, which uses a completely different mathema
That means mutations leading to a change of function in this part of the DNA are detrimental to the organism and will not become fixed in the genome, but rather discarded by natural selection. The level of conservation between species gives an idea of the relative “importance” of a stretch...
However, characteristics of Neurospora provide an easier method that depends on ascospore pigmentation, and this has been used to identify most of the Neurospora rearrangements that have been detected since 1950. Viable ascospores are black, but ascospores that contain a recombination-generated deficiency...
While the load of annotation may be alleviated by such computational approaches, the main challenge in modern annotation remains to develop a systems form of analysis in which a pipeline can effectively analyze gene-lists quickly and identify aggregated annotations through computerized resources. In ...
Engaging communication experts in a Delphi process to identify patient behaviors that could enhance communication in medical encounters p pBackground/p pThe communication literature currently focuses primarily on improving physicians verbal and non-verbal behaviors during the medical interv... JK Rao,LA ...
Although the DNA sequence of the human genome is known, it will probably take at least a decade to identify every gene and determine the precise amino acid sequence of the protein it produces. Yet the cells in our body do this thousands of times a second.FROM DNA TO RNA 331 FROM RNA ...
"What I wanted to do in this research, together with my colleagues, was to identify the original viral genome, because the virus mutates, it changes and you get variants arising. All these mutations have happened without anybody realizing a disease is among us," h...
The value of plant genome initiatives is self-evident. The need is to identify priorities for action. The angiosperm genome is highly variable, but the extent of this variability is unknown. Uncertainties remain about the number of genes and the number of species living. Many plants will become...
“We performed a large genetic association analysis to identify rare variants in non-coding genes that might be responsible for neurodevelopmental disorders,” says the study’s first author Daniel Greene, PhD, Assistant Professor of Genetics and Genomics Sciences at Icahn Mount Sinai and a Visitor ...