The DSBS:The Dynamic Small Business Search (DSBS)allows contractors and government agencies to search for small businesses that can meet their procurement needs. Getting listed on the DSBS can help prime contractors find your small business. The GSA:The General Services Administration (GSA) offers a...
This leaves between 60-95% of DSBs (depending on the organism) to be repaired as non-crossovers (NCOs), using the homolog as a template, or to be redirected for repair using the sister chromatid.Cell cycle
such that if you pulled on one you would bring its partner with it. It turns out that this temporary tying of the knot is a crucial part of the way that cells know that the two members of the chromosome pair are ready to be split up into different cells. Every...
The integrity of DNA in living organisms is challenged by various factors that inflict damage upon DNA, which then requires repair to maintain normal cell function (see Box 1 for details on DNA damage). Double-strand DNA breaks (DSBs), the most deleterious type of DNA lesions, can be repair...
We also look into current state-of-the-art technology that can be applied to harness and manipulate the epigenetic network so as to nudge CHO cells towards a specific phenotype. Here, we revise current strategies on site-directed integration and random as well as targeted epigenome modifications....
[39]. SLX4 provides a molecular platform to form a complex (SLX4com) with several SSEs, ERCC1-ERCC4/XPF, MUS81-EME1, but also SLX1, and stimulates their activities to coordinate the repair of specific replication-born double strand breaks (DSBs) and collapsed replication forks [38]-[40...