A matrix with three dimensions has the following identity matrix. How to calculate the inverse of a 2x2 matrix? A = [[a, b], [c, d]] To find the inverse A-1: Calculate the determinant of A: det(A) = ad - bc Find the adjoint of A: adj(A) = [[d, -b], [-c, a]] ...
5'-capping is critical for protecting mRNA from exonuclease activity, facilitating pre-mRNA splicing, and serving as the binding site for eIF4F, the heterodimeric translation initiation complex [46-49]. Recent studies have indicated the 5'-cap structure as a major determinant by which the host ...
In the 1960s, virology was still a young science, primarily dedicated to basic research. Its clinical relevance was limited. While scientists had been successful in propagating viruses of many major infections in cell cultures, these techniques were suboptimal for diagnosis of most viral diseases. I...
Infection with hepatitis B virus (HBV) may lead to acute or chronic hepatitis. HBV infections were previously much more frequent but there are still 240 million chronic HBV carriers today and ca. 620,000 die per year from the late sequelae liver cirrhosis or hepatocellular carcinoma. Hepatitis B...
Recently MEIS1 emerged as a major determinant of the MLL-r leukemic phenotype. The latest and most efficient drugs effectively decrease the levels of MEIS1 in cancer cells. Together with an overview of the latest drugs developed to target MEIS1 in MLL-r leukemia, we review, in detail, th...
The transmembrane aspartic protease β-site APP cleaving enzyme 1 (BACE1) has been identified as the essential β-secretase, which is a major determinant that predisposes the brain to Aβ amyloidogenesis. This enzyme is in high amounts in the brain with sporadic onset AD, and an its ...