Technical Note: Understanding the Mechanisms of Transcription. Despite recent advances in our understanding of the genome, there are still large gaps in our knowledge of the basic biology involved in gene expression. A particularly important questionremains: what exactly causes a cell to make a prote...
Recent evidence has elucidated how multipotent blood progenitors transform their identities in the thymus and undergo commitment to become T cells. Together with environmental signals, a core group of transcription factors have essential roles in this process by directly activating and repressing specific ...
Program in Cell and Molecular BiologyL. ChenProgram in Cell and Molecular BiologyK. M. CadiganProgram in Cell and Molecular BiologyActa PhysiologicaArchbold H. C., Yang Y. X., Chen L., Cadigan K. M. (2012). How do they do Wnt they do?: regulation of transcription by the Wnt/beta...
DNA, rather famously, is woven into a double-stranded helix. But in this form, it would physically be difficult to build anything from it. Therefore, in theinitiationphase (or step) of transcription, the DNA molecule is unwound by enzymes called helicases. Only one of the two resulting DNA...
A process in biology in which a well-mixed solution of molecules separates (demixes) into two coexisting phases, with one phase being denser (higher molecular concentration) than the other. Stress granules Membraneless, cytoplasmic ribonucleoprotein cell compartments that form in response to different ...
Certificate programs cover the basic technical skills and knowledge needed to succeed in the profession such as proofreading, editing, using transcription equipment, and medical terminology. Certificate programs may also include courses in biology and anatomy/physiology and teach students about computer tec...
Only six substitutions occur at the substrate-binding surface, and the others change domain–domain interfaces in the polymerase to enable RNA–DNA hybrid binding and reverse transcription. Most notably, F587L at the Palm and Thumb interface stabilizes the open and apo conformation of the Thumb. ...
Potential roles for haplotype and mRNA diversity, differential haplotype-specific transcriptional activity, and altered transcription fact... Polymorphisms in CC chemokine receptor 5 (CCR5), the major coreceptor of human immunodeficiency virus 1 (HIV-1) and simian immunodeficiency virus (SIV), have a ...
A male bias in mortality has emerged in the COVID-19 pandemic, which is consistent with the pathogenesis of other viral infections. Biological sex differences may manifest themselves in susceptibility to infection, early pathogenesis, innate viral contro
Transcription Process by which the information in a strand of DNA is copied into a new molecule of messenger RNA. Vertex models A class of mathematical models that treat cells as individual objects, represented by polygons in two dimensions and polyhedra in three dimensions. Epithelial tissues are...