which demonstrates that the clinical benefit from therapy relates more directly to the decrease in number of apoB particles than to the decrease in LDL-C and the atherogenic risk attributable to a very-low-density lipoprotein (VLDL) apoB particle is the same as that due to a LDL apoB parti...
1) Calcium scoring may be superior to angiography as a means to track plaque. That’s because the vast majority of heart attacks are due to plaque rupture and thrombosis at areas of thickened plaque with minimal lumen narrowing. Over time, the body’s healing process automatically remodels the...
β-site specific intrabodies to decrease and prevent generation of Alzheimer's Aβ peptide Endoproteolysis of the β-amyloid precursor protein (APP) by β- and γ-secretases generates the toxic amyloid β-peptide (Aβ), which accumulates in the b... P Paganetti,V Calanca,C Galli,... -...
Decreased AQP8 could decrease biliary cholesterol secretion and water secretion into bile [55] and conceivably increase circulating cholesterol. COMB affected transcripts involved in apolipoprotein metabolism (apoa4, apoc2), PL transport (pltp, phospholipid transfer protein), and oxysterol binding (osbpl...
Similar to LDL, an Lp(a) particle also contains one molecule ofapolipoprotein B (apoB). Lipoproteins that promote atherosclerosis (the leading underlying cause of heart disease) are termed atherogenic. ApoB is an essential component of all atherogenic lipoproteins. ...
Alzheimer's disease is known to be associated with variation in the apolipoprotein E gene (APOE). The therapeutic response in AD is genotype-specific, with APOE*4/4 carriers representing the worst responders to conventional treatments,114 such as donepezil, rivastig- mine, galantamine, and ...
, type C1 (NPC1) is a membrane protein that facilitates the egress of cholesterol from late endosomes and lysosomes into the cytosol. Inhibition of NPC1 through both pharmacological and genetic means reduces NLRP3 activation due to the decrease in cholesterol flow into the cytoplasm [60]. To...
added to maximally tolerated statin therapy in patients at high risk for CVD significantly reduced LDL-C by 36% at week 12 compared with 17% for bempedoic acid alone or 23% for ezetimibe alone; similar results were observed with non–HDL-C, total cholesterol and apolipoprotein B (ApoB) [...
3. Decrease Body Weight If you’re currently overweight, losing even a few pounds can improve your HDL cholesterol. For every six pounds of weight you lose, your HDL canincreaseby 1 milligram per deciliter. That’s means you want tolose weight, and if you’re extremely overweight, getting...
ApoER2, apolipoprotein E receptor 2; EMPs, endothelial microparticles; eNOS, endothelial nitric oxide synthase; GPIIb/IIIa, glycoprotein IIb/IIIa; mTOR, mammalian target of rapamycin; NETs, neutrophil extracellular traps; PAR, protease-activated receptor; PF4, platelet factor 4; PI3K, phosphatidylinosito...