Antimicrobial resistance (AMR) is an urgent public health threat. Advancements in artificial intelligence (AI) and increases in computational power have resulted in the adoption of AI for biological tasks. This review explores the application of AI in ba
To address this issue, we recently launched the TmAlphaFold database, where predicted AlphaFold2 structures are embedded into the membrane plane and a quality assessment (plausibility of the membrane-embedded structure) is provided for each prediction using geometrical evaluation. In this paper, we ...
In 2003, the Worldwide PDB was created to ensure that there would be a single global archive for structural data and that deposited data would be processed with uniform standards (3). The initial members were the RCSB PDB, Macromolecular Structure Database (MSD) later called Protein Data Bank...
related viruses, namely of SARS-CoV-1 in China and Canada in February 2003, and of the Middle East respiratory syndrome coronavirus (MERS-CoV) since April 2012, lead to depositions of 43 SARS-CoV–1 and 29 MERS-CoV structures of the spike in the Protein Data Bank (PDB) [Citation114]....
Following several years of community discussion, the Protein Data Bank (PDB) was established in 1971 as a public repository for the coordinates of three-dimensional models of biological macromolecules. Since then, the number, size, and complexity of structural models have continued to grow, ...
Hsp90 is an essential molecular chaperone responsible for the folding and activation of hundreds of ‘client’ proteins, including the glucocorticoid receptor (GR). Previously, we revealed that Hsp70 and Hsp90 remodel the conformation of GR to regulate l
The secondary structure of an RNA must be known before the relationship between its structure and function can be determined. One way to predict the secondary structure of an RNA is to identify covarying residues that maintain the pairings (Watson-Crick,
(in green, PDB ID:1pq1B;Figure 3a), including the BH3 domain, that binds to the groove of Bcl-Xl, which is composed of eight helices (gray, 1pq1A). The region was shown to be disordered in the isolated form using CD [28]. The values for pLDDT, mrASA, and %Helix were 82.2%,...
There is a number of databases storing information about various aspects of biologically active compounds—from data on compounds activity towards particular target, such as the ChEMBL database [9] or PDSP [10], through the information on 3-dimensional structure of proteins (PDB) [11], data on...
Link to this page: Facebook Twitter Complete English Grammar Rules is now available in paperback and eBook formats. Make it yours today! Advertisement. Bad banner? Pleaselet us knowRemove Ads