Reprints and permission information is available online at http://npg.nature.com/ reprintsandpermissions/ How to cite this article: Volbeda, A. et al. Crystal structures of the NO sensor NsrR reveal how its iron-sulfur cluster modulates DNA binding. Nat. Commun. 8, 15052 doi: 10.1038/n...
Hsp90 is an essential molecular chaperone responsible for the folding and activation of hundreds of ‘client’ proteins, including the glucocorticoid receptor (GR). Previously, we revealed that Hsp70 and Hsp90 remodel the conformation of GR to regulate l
Due to the presence of divalent calcium ions in all crystallisation conditions, we could not soak the crystals with nucleotides which immediately precipitate; transferring crystals to a solution devoid of Ca2+dissolved them in a matter of seconds. On the other hand, there are several AEP structures...
This sequence alignment was drawn by Clustal Omega service Full size image Structural protein interactions The S-protein N-terminal signal sequence helps this protein by guiding it to the endoplasmic reticulum. Interactions between the spike and M proteins are not significant to the viral particles ...
Hsp90 is an essential molecular chaperone responsible for the folding and activation of hundreds of ‘client’ proteins, including the glucocorticoid receptor (GR). Previously, we revealed that Hsp70 and Hsp90 remodel the conformation of GR to regulate l
The total COI region sequences were submitted to GenBank using Basic Local Alignment Search Tool (BLAST) [39] and were then aligned with highly similar sequences using the Clustal W algorithm implemented in MEGA v7 (http://multalin.toulouse.inra.fr/multalin/, accessed on 29 January 2021) [...
The variable length C-terminals past the second coiled-coil are not shown but ranged between 45 to 178 amino acids and had only 20% similarity by Clustal Omega. Uniprot also predicts that large parts of the different RIC-3 species C-terminals are intrinsically disordered, but Alphafold predicts...
Ticks are the vector of many human and animal diseases; and host detection is critical to this process. Ticks have a unique sensory structure located exclusively on the 1st pairs of legs; the fore-tarsal Haller’s organ, not found in any other animals, presumed to function like the insect ...