Hsp90 is an essential molecular chaperone responsible for the folding and activation of hundreds of ‘client’ proteins, including the glucocorticoid receptor (GR). Previously, we revealed that Hsp70 and Hsp90 remodel the conformation of GR to regulate l
This study has analyzed the presence of a furin-like cleavage site in the S protein of recently emerged coronaviruses, SARS-CoV-2, SARS-CoV, and MERS-CoV, using the Clustal omega tool. The results confirmed its absence in SARS-CoV and its presence in the other two coronaviruses (Fig. ...
Due to the presence of divalent calcium ions in all crystallisation conditions, we could not soak the crystals with nucleotides which immediately precipitate; transferring crystals to a solution devoid of Ca2+dissolved them in a matter of seconds. On the other hand, there are several AEP structures...
Hsp90 is an essential molecular chaperone responsible for the folding and activation of hundreds of ‘client’ proteins, including the glucocorticoid receptor (GR). Previously, we revealed that Hsp70 and Hsp90 remodel the conformation of GR to regulate l
3. Results 3.1. Stranded Individuals and Occasional Catches Overall, during the entire sampling period, 47 fresh specimens belonging to Argonautoidea were collected (Table S1). Most of them were found/caught in the Strait of Messina (87.2% of samples), and 42.6% were A. argo. Most individua...