These properties were represented among the 20 descriptors that were used to calculate the PCA and therefore were accounted for in the overlapping scores. It is therefore not surprising to picture these datasets as close in chemical space. In fact, it is clearly visible from the surface map of...
Some soluble, misfolded proteins can bypass the refolding action of chaperones in vivo according to folding and functional assays1,2,3. Typically, in these assays the protein of interest is purified after it has been expressed either heterologously or constitutively from different synonymous messenger ...
Which buffer system is the best choice to create a buffer with pH=7.20? For the best system, calculate the ratio of the masses of the buffer components required to make the buffer. HC2H3O2/KC2H3O2 H If you were conducting an experiment with pepsin, which has optimal e...
Retrospectively analyzing data from the Cooperative Study of Sickle Cell Disease (CSSCD) to calculate incidence rates for first-time VTE, Naik and colleagues found an incidence rate of 5.2 events per 1000 person-years (95% confidence interval [CI], 3.8-6.9) in 1523 SCD patients aged ≥15 ...
Error bars in (B), (C) and (D) represent SEM of triplicate data used to calculate the representative IC50 values in (A). (E) Location of BimBH3 ‘h0’ and h1 residues in the proposed alternative Bax binding site, the α1/α6 interface (Gavathiotis et al., 2008). The model ...
We next asked how it is possible that long-lived misfolded proteins are able to bypass the post-translational cellular chaperone machinery. To address this question we used coarse-grained Langevin dynamics to calculate the dissociation constant between the chaperone GroEL and three distinct conformational...
We next asked how it is possible that long-lived misfolded proteins are able to bypass the post-translational cellular chaperone machinery. To address this question we used coarse-grained Langevin dynamics to calculate the dissociation constant between the chaperone GroEL and three distinct conformational...
While these models have proven to be effective when describing small-scale/ narrowly defined conformational transitions, the vast phase space associated with accommodation makes it computationally intractable to calculate the free energy. In contrast, through the use of simpler models, one may evaluate ...
the vast phase space associated with accommodation makes it computationally intractable to calculate the free energy. In contrast, through the use of simpler models, one may evaluate and compare the free energy of accommodation for a variety of molecular constructs. In the current study, we adopt ...
As the skin is exposed to multiple exogenous factors that may lead to epidermal barrier (EB) impairment, the SC is continuously active in maintaining a functional physiologic state by resorting to a variety of self-repair mechanisms. Once transepidermal water loss (TEWL) is increased beyond the ...