we need to look at the aggregate of genes; moreover, we need more than one ‘omic-wide’ dataset to not miss something important.” Van Duijn, leads the human proteomics and metabolomics discovery research
identify patterns, and make predictions or classifications based on the learned patterns. In the context of multi-modal signatures,ML algorithms can analyse complex and heterogeneous datafrom various sources
In general, ML methods used to analyse plant stress data rely on approaches that are able to learn from a priori (“supervised”), inductive (“unsupervised”), and reward-based (“reinforcement”) experience [62].“Supervised” algorithms are based on the training of models containing previousl...
Metabolomics The systematic study of a metabolome, which is the collection of all the metabolites in a biological cell, tissue, organ or organism. One-component signal transduction systems Signal-sensing and response systems in which the signal transducer is the direct fusion of an input domain to...
(E) Two-dimensional GC coupled to time-of-flight mass spectrometry (GC×GC-TOF) is used for small molecule metabolomics and (F–G) liquid chromatography-mass spectrometry (LC-MS) is commonly used in lipidomics. (H) Data mining and processing methods are needed to analyse the data. ...
“More researchers are using shotgun metagenomics alone or in combination with one other approach such as community metabolomics,” says Curtis Huttenhower, a computational microbiologist at the Harvard T.H. Chan School of Public Health in Boston. “Linking sequencing with high-throughput molecular too...
From a computational standpoint, there are a number of workflows to analyse metatranscriptomics data, many of which adapt tools that might not be specifically designed for the analysis of RNA from microbial communities [151]. In particular, researchers have not yet made the same efforts towards ben...
Its main goal is to improve the outcome of cancer patients. It will analyse 100,000 samples in comparison with clinical data to find out how to best use genomic knowledge in the prevention, detection and treatment of cancers [52,54]. Projects, as described above, have enabled the creation ...
The aim of this study was to analyse this effect by a vaquejada simulation test (VST), in order to evaluate energy expenditure (EE), transport cost (COT) and metabolic energy requirement (Pmet) in horses. Eight Quarter Horses were evaluated in a VST composed of three races (130–150 m ...
(ERA-IB BB/M004570/1), as well as by a grant from the Sächsische Staatsministerium für Wissenschaft und Kunst (SMWK) to J.L-M. and K.-H.v.P and by Open Access Funding by the Publication Fund of the TU Dresden. Acknowledgments We thank Lionel Hill of the metabolomics faculty ...