The FDR estimation methods presented will enable a user to assess the scoring criteria for large scale analysis of mass spectrometry based metabolomics data that has been essential in the advancement of proteomics, transcriptomics, and genomics science....
SIGNIFICANCE OF NMR-BASED METABOLOMICS (METABOLOME) FOR THE PREDICTION OF MALIGNANT-TYPE MENINGIOMA USING THE ANALYSIS OF WATER- AND LIPID-SOLUBLE METABOLITESTakahashi, HiroshiHirakawa, KeikoOhno, YoukichiTeramoto, AkiraYuta, Kohtaro
Metabolomics analysis II. Preparation of biological samples prior to detection. Trends Anal Chem. 2010;29:120–7. Article Google Scholar Garcia A, Barbas C. Gas chromatography–mass spectrometry (GC-MS)-based metabolomics. In: Metz TO, editor. Metabolic profiling, methods in molecular biology ...
Summary: We have developed a program for microarray data analysis, which features the False Discovery Rate (FDR) for testing statistical significance and the Principal Component Analysis (PCA) using the Singular Value Decomposition (SVD) method for detecting the global trends of gene expression pattern...
Metabolomics13uses small-molecule metabolites as research objects, using high-precision analytical methods and bioinformatics tools to target all small-molecule metabolites (< 1000 relative molecular mass) in all tissues and cells for quantitative analysis14, which directly reflects the biochemical state...
Cui J, Sun T, Li S et al (2020) Improved salt tolerance and metabolomics analysis of Synechococcus elongatus UTEX 2973 by overexpressing Mrp Antiporters. Front Bioeng Biotechnol 8:500. https://doi.org/10.3389/fbioe.2020.00500 Article PubMed PubMed Central Google Scholar Davies FK, Work VH,...
Identification of differentially regulated metabolomics variates for a specific clinical outcome devtools::install_github("AlinaPeluso/PhenoMeNal", subdir="MWSL") library(MWSL) Section 1: Exploratory analysis We aim to investigate the association between human serum 1H NMR metabolic profiles and various cl...
The measured median biological CV together with analysis of intragroup variation of healthy individuals suggests that fold changes above 2 in metabolomics studies investigating plasma or CSF are statistically relevant with respect to the inherent variability of a healthy control group. These data ...
Thus, to overcome these aforementioned shortcomings, we analyzed the metabolite profile of BM plasma samples obtained prospectively in a manner suitable for metabolomics studies from patients with MGUS and MM undergoing clinical BM aspirations. We utilized untargeted metabolite profiling to identify ...
It provides a suite of tools for gene functional annotation, enrichment analysis, and functional annotation clustering, which aids in the comprehensive biological interpretation of large-scale omics data, including transcriptomics, proteomics, and metabolomics. DAVID helps researchers identify biological ...