SIGNIFICANCE OF NMR-BASED METABOLOMICS (METABOLOME) FOR THE PREDICTION OF MALIGNANT-TYPE MENINGIOMA USING THE ANALYSIS OF WATER- AND LIPID-SOLUBLE METABOLITESTakahashi, HiroshiHirakawa, KeikoOhno, YoukichiTeramoto, AkiraYuta, Kohtaro
The FDR estimation methods presented will enable a user to assess the scoring criteria for large scale analysis of mass spectrometry based metabolomics data that has been essential in the advancement of proteomics, transcriptomics, and genomics science....
(tissues, cells, fluids, or organisms) under normal conditions in comparison with altered states promoted by disease, drug treatment, dietary intervention, or environmental modulation. The aim of this chapter is to review the fundamentals and definitions used in the metabolomics field, as well as ...
Metabolomics13uses small-molecule metabolites as research objects, using high-precision analytical methods and bioinformatics tools to target all small-molecule metabolites (< 1000 relative molecular mass) in all tissues and cells for quantitative analysis14, which directly reflects the biochemical state ...
Identification of differentially regulated metabolomics variates for a specific clinical outcome devtools::install_github("AlinaPeluso/PhenoMeNal", subdir="MWSL") library(MWSL) Section 1: Exploratory analysis We aim to investigate the association between human serum 1H NMR metabolic profiles and various cl...
Metabolic flux analysis INST-MFA: Isotopically nonstationary13C Metabolic flux analysis GG: Glucosylglycerol DES: Diethyl sulfate Nano LC-MS/MS: Nano-liquid chromatography and mass spectroscopy ADP: Adenosine Diphosphate PCs: Phycocyanins MEP:
which aids in the comprehensive biological interpretation of large-scale omics data, including transcriptomics, proteomics, and metabolomics. DAVID helps researchers identify biological themes, molecular pathways, and disease associations related to their genes of interest by integrating multiple functional anno...
Recently, metabolomics analysis of duodenal juice in patients with BTC and benign biliary lesions identified acetone as a predictive factor of malignancy, with an area under the curve value of 0.733.117 A panel of 10 metabolites determined in the plasma of patients with iCCA has been proposed to...
(in this case, the metabolite profile of the bone marrow (BM) plasma) should subsequently reflect the antecedent changes in the various intracellular metabolic pathways of the clonal PCs located within the BM. Metabolomics can play a key role in differentiating between different cellular metabolic ...
Lipid analysis of epidermal and dermal cell membranes showed that they contain twelve types of these compounds, including phospholipids, such as phosphatidic acid (PA), phosphatidylethanolamines (PE), cardiolipins (CL), phosphatidylserine (PS), lysophosphatidylcholines (LPC), phosphatidylinositols (PI)...