In patients at high risk of early death (age above 80, or age 65 or older with Zubrod performance status 3-4), I administer intravenous itraconazole or liposomal amphotericin prophylactically and, if not given prophylactically, begin amphotericin, and attempt to arrange granulocyte transfusions ...
This is due to weak health care systems and low cancer literacy, which contribute to late diagnosis, and inability to administer and support patients through high-intensity cytotoxic treatment. As a result, tumors are larger, disease stage higher, achievable treatment intensity lower, and treatment-...