54 However, whether all patients with R/R AML benefit from salvage therapy with the attempt to induce CR beforeallogeneic HCT is not known and was studied in a recent phase 3 trial randomly assigning patients 1:1 to a remission induction strategy (RIST-arm) with high-dose cytarabine and ...
Patients (pts) received 8 cycles of hyper-CVAD alternating with high-dose methotrexate/cytarabine approximately every 21 days. Initially, ponatinib was given at 45 mg daily for the first 14 days of cycle 1 then continuously for the subsequent cycles. Rituximab was administered during the first 4...
if the causative drug has a direct effect on the cardiovascular system that leads to decreased left ventricular function, the pathology is similar to cardiogenic pulmonary edema. Drugs reported to induce NCPE include cytarabine arabinoside (Ara-C), gemcitabine (GEM), MTX, amphotericin B (AMPH-B...
BACKGROUND: About 65 percent of previously untreated adults with primary acute myeloid leukemia (AML) enter complete remission when treated with cytarabine... RJ Mayer,RB Davis,CA Schiffer,... - 《N Engl J Med》 被引量: 3412发表: 1994年 Multifactor-dimensionality reduction reveals high-order ...
In an ideal patient, such as one who is younger, with a core binding factor cytogenetic abnormality, and who is given standard anthracycline- and cytarabine-based induction chemotherapy, complete remission (CR) rates approach 85%, with long-term disease-free survival (DFS) rates of 60% or gre...
The three agents mainly used for intra-CSF treatment of leptomeningeal metastasis are methotrexate, (liposomal) cytarabine and thiotepa. Other compounds are also under evaluation. Trastuzumab has been evaluated in a phase I study in patients with breast cancer with leptomeningeal metastases with Her2-...
prolonged QT syndrome 7% have an increase from baseline QTc >60 ms; prolonged interval >500 ms is rare (1%); if QTcF >500 ms, interrupt gilteritinib and resume at 80 mg when QTc interval returns to ≤480 ms; substitute QT prolonging with non-QT prolonging coadministered drugs if ...
Cytarabine 50 mg/m2 2× daily SC; days 2-6 Alkaline hydration administered 2 h before and 2 h after methotrexate Methotrexate 12 mg IT; day 2 Methotrexate 1 g/m2 in 2001 protocol safely escalated to 3 g/m2 in 2009 protocol Cytarabine 50 mg IT; day 7 ANC, absolute neutrophil count; ...
Notably, a combination of NOB and cytarabine, a chemotherapeutic agent, remarkably decreases c-kit expression in AML therapy [234]. 5.9. Anti-angiogenesis Effect The process of sprouting new blood vessels from pre-existing ones is defined as angiogenesis [235]. This process is active during ...
However, topically administered growth factors, in particular in chronic wounds, have shown limited success which may be a result of several biological events. Firstly, proteases activated at the injury site are able to degrade both endogenous and exogenous growth factors and other signaling molecules...