Introduction: Lynch syndrome (LS) is an inherited cancer predisposition syndrome characterized by a high risk of colorectal and extracolonic tumors. Germline pathogenic variants (GPV) in the PMS2 gene are associated with <15% of all cases. The PMS2CL pseudogene presents high ...
The ability ofS. mutansto exert its pathogenicity is largely attributed to the production of EPS. EPS, a major component of biofilms38, consists of extracellular proteins, extracellular DNA, and lipoteichoic acid39. The primary component of EPS is glucan, which is synthesized by Gtf40, providing...
The ability ofS. mutansto exert its pathogenicity is largely attributed to the production of EPS. EPS, a major component of biofilms38, consists of extracellular proteins, extracellular DNA, and lipoteichoic acid39. The primary component of EPS is glucan, which is synthesized by Gtf40, providing...
The concept of gene is no longer the main element of the genome. The reason for this is that it is not always feasible to describe the DNA structure in terms of genes. The main element is the chromosome element. This change allows any relevant part of the genome (not just genes) to ...
Systemic lupus erythematosus (SLE or lupus) is an immune-mediated disease associated with substantial medical burden. Notably, lupus exhibits a striking female bias, with women having significantly higher susceptibility compared to men, up to 14-fold hig
prevalent form of DNA methylation in prokaryotes where it is used to distinguish benign host DNA from potentially pathogenic nonhost DNA6. Although under debate7, there is also evidence for m6A in mammalian DNA where it is proposed to play roles in transcription suppression and gene silencing8,9...
To ensure that the sample does not leak under the agar layer, fixed agar is left on the bottom of the hole (Cole, 1994). The small sample requirements and the possibility to test up to six extracts per plate against a single micro-organism are specific advantages (Hadacek and Greger, ...
“rapidly adapt to replication in mammals”, which “may increase the risk for transmission to humans”. They conclude, “although the chance that such mutations will arise in an infected animal is very small, the impact of the emergence of a zoonotic virus with potentially pandemic ...
Streptococcus suis is a zoonotic agent that causes sepsis and meningitis in pigs and humans. S. suis infections are responsible for large economic losses in pig production. The lack of effective vaccines to prevent the disease has promoted the extensive
in these assays the protein of interest is purified after it has been expressed either heterologously or constitutively from different synonymous messenger RNA (mRNA) variants. A synonymous mRNA variant is an mRNA molecule where one or more codons have been replaced by a synonymous codon, which doe...