piscicida genomes have undergone an expansion of insertion sequence (IS) elements that caused a massive gene decay, a process likely fueled by its host-dependent lifestyle. The repertoire of horizontally acquire
B. et al. Surface expression of Toll-like receptor 9 is upregulated on intestinal epithelial cells in response to pathogenic bacterial DNA. Infect. Immun. 75, 2572–2579 (2007). Article CAS PubMed PubMed Central Google Scholar Moran, G. W., Leslie, F. C., Levison, S. E. & ...
This will lead the investiga- tor to understand whether the variant has any possible functional implications or not. If there is no correlation, the VUS may get designation shift from class 3 to class 2 (not likely pathogenic). But, on the contrary, if reverse Banerjee et al. Middle...
As this incomplete overview of molecular mechanisms shows, skin aging is a multi-causal process with loss of tissue and cell homeostasis, loss of proteostasis, increased protein oxidation, reduced immune capacities for senescence clearance, impaired DNA repair competence and others. Thus, it can be ...
At least part of these transcripts is likely to participate in RNAi-mediated regulation of gene expression. The hypothesis We propose a hypothesis that virus suppression mediated by self-encoded small interfering RNAs is not an exception but is rather a general case for the mammalian genomes and,...
2,4,6 A third type of descending interneuron is ACh+/SST+ and is involved in small intestinal migrating myoelectric complexes. Whereas the other two interneuron subtypes are characterized by Dogiel type I morphology in guinea pig and mouse, this third subtype is characterized by distinct ...
This study uses a large plant–pathogen protein interaction screen involving a high-throughput yeast two-hybrid assay to show that pathogen effectors target a relatively small set of interconnected host signalling hubs, some of which seem to be monitored by immune receptors. Article CAS PubMed Pub...
TP53is a tumor suppressor gene involved in multiple cellular processes that coordinate DNA damage response [1]. SomaticTP53pathogenic variants (PVs) occur in most tumor types, and when present in the germline, they cause an autosomal dominant cancer susceptibility condition called Li-Fraumeni syndrome...
Streptococcus suis is a zoonotic agent that causes sepsis and meningitis in pigs and humans. S. suis infections are responsible for large economic losses in pig production. The lack of effective vaccines to prevent the disease has promoted the extensive
Systemic lupus erythematosus (SLE or lupus) is an immune-mediated disease associated with substantial medical burden. Notably, lupus exhibits a striking female bias, with women having significantly higher susceptibility compared to men, up to 14-fold hig