Laypersons have a strong need to explain critical life events, such as the development of an illness. Expert explanations do not always match the beliefs of patients. We therefore assessed causal attributions made by women with a pathogenic germline variant in BRCA1/2 (gBRCA1/2-PV), both ...
"It is also noted that by infecting many more people, a very infectious virus may cause more severe disease and death even though the virus itself may be less pathogenic(致病的)," he said. "Therefore, taken together with our recent studies showing that the Omicron variant can partially ...
What is plant virology? What are some microorganisms studied in virology? What does NA in virology stand for? What is a dominant repressive factor in virology? What does HPI stand for in virology? What is a variant in the case of virology?
In the present study, a novel variant in DEPDC5 was detected in the patient with focal epilepsy and his healthy father. We aimed to analyze the pathogenic DEPDC5 variant in the small family of three. Case presentation A 5-month-old male infant presented with focal epilepsy. Whole exome ...
Rana: So genetic testing is testing that is done to analyze genes for variations. Some of those variations, in particular, if they're found to be mutations, and we call those likely pathogenic or pathogenic results, then that can tell us that we have an increased risk for certain conditions...
A new recommendation was added “For younger (eg, age ≤45 years) patients with nonobstructive HCM due to a pathogenic or likely pathogenic cardiac sarcomere genetic variant, and a mild phenotype, valsartan may be beneficial to slow progression of the disease.”...
This is known as CRISPR activation (CRISPRa) and CRISPR interference (CRISPRi). CRISPRa is used to increase (upregulate) the expression of a gene, while CRISPRi can reduce (downregulate) the expression of a gene. Both of these technologies function by fusing an engineered variant of Cas9 ...
The Omicron sublineage BA.5 is a more contagious variant. It spreads faster and has an improved capability to escape the immune system, experts said. 南非最新研究结果表示,BA.5变异毒株的R0值高达18.6,传播性是原始毒株的6...
Today, PD is exclusively treated symptomatically, mainly by dopaminergic stimulation, while efforts to modify disease progression could not yet be translated to the clinics. New formulations of approved drugs and treatment options of motor fluctuations in advanced stages accompanied by telehealth ...
When the parents are asymptomatic (as in most cases), a de novo variant is likely to be pathogenic, and an inherited alteration is likely to be benign. However, parental testing may not completely clarify the clinical significance of the alteration. When a novel de novo change is identified,...