Comparative genomic hybridization (CGH) allows the detection of whole genome copy number variation (duplication and deletion) at high resolution [10]; 4. New Generation Sequencing (NGS) provided a large boost fo
Whole-exome or whole-genome sequencing are options, “but both the cost and analytical work involved are prohibitive at this stage,” he says. Horizon scores gRNAs for off-target potential during the design stages, and only top scorers that show cutting activity in cell-based assays progress ...
vaccination is used to prevent infection, but its efficacy is limited. Only bacterins are applied in the field for immunization of piglets or sows. Bacterins are suspensions of whole killed bacteria prepared from invasive clones collected in certain farms...
However, there is much controversy in high-grade BCLs with regards to the benefits of IT vs effective systemic therapy which crosses the blood-brain barrier, which may overcome the limitations of IT therapy and achieve even and predictable concentrations throughout both the leptomeningeal and parenchy...
Next-generation sequencing has provided a more complete picture of the composition of the human transcriptome indicating that much of the “blueprint” is a vastness of poorly understood non-protein-coding transcripts. This includes a newly identified class of genes called long noncoding RNAs (lncRNA...
The pace of exome and genome sequencing is accelerating, with the identification of many new disease-causing mutations in research settings, and it is likely that whole exome or genome sequencing could have a major impact in the clinical arena in the rel
(Taubenberger and Kash, 2010), is stipulated by the fact that the RNA-dependent RNA polymerase of influenza viruses does not have an active correction site (Steinhauer et al., 1989; Cheung et al., 2014). This leads to a high frequency of point mutations in the course of RNA genome ...
However, clinical genomic sequencing produces large amounts of data, much of which is hard to characterize or may have a negligible influence on health. Thus, one of the first questions that these programs face regards actionability: how to assess which types of genomic data have enough ...