The pace of exome and genome sequencing is accelerating, with the identification of many new disease-causing mutations in research settings, and it is likely that whole exome or genome sequencing could have a major impact in the clinical arena in the rel
vaccination is used to prevent infection, but its efficacy is limited. Only bacterins are applied in the field for immunization of piglets or sows. Bacterins are suspensions of whole killed bacteria prepared from invasive clones collected in certain farms...
Genet Med advance online publication 29 January 2015 Key Words: genetic education; medical education; personal genomes; whole-genome sequencing INTRODUCTION Whole-exome sequencing (WES)/whole-genome sequencing (WGS) is now used routinely in research and clinical applications. The demand for WES/WGS ...
Structural elements of the type A influenza virus. HA—hemagglutinin (trimer), NA—neuraminidase (tetramer), M1—matrix protein 1, M2—matrix protein 2, ME—phospholipid membrane, NEP—nuclear exporter protein, RNA—negative-strand RNA in ribonucleoprotein segments, NP—nucleocapsid protein, PA—acidi...
[143] evaluated the performance of 69 SV detection algorithms using whole exome sequencing (WES) datasets, using the GRIDSS, Lumpy, SVseq2, SoftSV, Manta, and Wham algorithms to improve variant detection accuracy, focusing on SV size. This means that careful selection of algorithms for each ...
Next generation sequencing (NGS) technologies can provide data on complete genomes (whole genome sequencing, WGS), or the coding sequences (whole exome sequencing, WES) [16]. It is mostly used to identify some rare genetic variants which cannot be revealed by GWAS. NGS has now become the ...
However, clinical genomic sequencing produces large amounts of data, much of which is hard to characterize or may have a negligible influence on health. Thus, one of the first questions that these programs face regards actionability: how to assess which types of genomic data have enough ...
The mechanisms responsible for the release of the precursors from the plastid and the ER have not yet been identified, while much information regarding the GA movement across the plasma membrane is available. Indeed, GA moves between cells through different mechanisms, with the ion trap being the...
If we look at a single gene, the amount of read is much deeper; however, in a targeted panel, the amount of depth decreases, while in exome and whole genome sequencing the depth decreases even further. Another point to consider is that the more information we have, the more the back...