Functional 50 UTR mRNA structures in eukary- otic translation regulation and how to find them. Nat Rev Mol Cell Biol 2017;4:1.Leppek, K.; Das, R.; Barna, M. Functional 5' UTR mRNA structures in eukaryotic trans
Ultraviolet (UV) radiation is a ubiquitous component of the environment that has important effects on a wide range of cell functions. Short-wavelength UVB radiation induces sunburn and is a potent immunomodulator, yet longer-wavelength, lower-energy UVA radiation also has effects on mammalian immunity...
Describe how eukaryotic mRNA is processed before leaving the nucleus. Why is RNA-seq "better" than Microarrays? What are the locations of RNA translation? How do RNA polymerases differ from DNA polymerases? A) Why doesn't RNA polymerase have to proofread, or more specifically why isn't it ...
2.2. Base modifications improve translation in the spleen in a nanoparticle-dependent manner To determine the influence of mRNA modifications on protein translation, we combinatorially formulated nanoparticles with the four lipids and five modified mRNAs encoding mLuc. Nanoparticles were injected intravenously...
Why is there no RNA in the nucleus? How is mRNA splicing regulated? How does splicing of pre-mRNA occur? Describe how the RNA transcript is modified before it can be used to make proteins. Can you explain the DNA-RNA-PROTEIN concept? Why is DNA stable but RNA is not? How do RNA an...
Dmitriev, S. E. et al. Efficient translation initiation directed by the 900-nucleotide-long and GC-rich 5′ untranslated region of the human retrotransposon LINE-1 mRNA is strictly cap dependent rather than internal ribosome entry site mediated.Mol. Cell. Biol.27 ...
(red) and mRNA (black) reveals loss of oligodendrocytes within the lesion and the presence of numerous macrophages with PLP degradation products at the lesion edge; e: In sections stained for phosphorylated neurofilament only a mild to moderate reduction of axonal density is seen in the lesions;...
In this transition period, a rapid rearrangement of the various signaling pathways occurs, which, primarily, results in a decrease in the rate of protein synthesis (primarily via inhibition of ribosomal biogenesis and activation of endogenous inhibitors of mRNA translation, such as...
mRNA 5′ untranslated regions (UTRs), which serve as the entry point for the ribosome during translation, can adopt elaborate RNA secondary and tertiary structures that may regulate translation initiation in a cap-dependent or cap-independent manner. Complex RNA structures in 5′ UTRs, such as ...
Describe how the RNA transcript is modified before it can be used to make proteins. How do I transcribe DNA to mRNA and mRNA to protein? How is RNA therapy given? Why does DNA not form protein directly? Why does DNA depend on RNA?