Trastuzumab is a recombinant DNA-derived humanized monoclonal antibody produced by suspension culture of mammalian cells (Chinese hamster ovary cells) in a sterile culture medium. The purification process includes specific virus inactivation and removal steps using affinity chromatography and ion exchange. M...
While more long-term follow up is needed, this study suggests that surgical axillary staging may be omitted in certain low-risk populations due to the efficacy of NAC and radiation as well as the increasing use of radiosensitizing agents such as capecitabine, Trastuzumab emtansine, Olapa- rib ...
Interferons are cytokines produced by immune cells and fibroblasts and are part of the nonspecific immune response. Interferon alpha is produced naturally by leucocytes. Interferon-beta is produced by fibroblasts. Interferon-gamma is produced by T cells and NK cells.54Interferons are used for various ...
For example, structural studies of anti-her2 antibodies determined that they bind to distinct antigenic epitopes, explaining the molecular underpinnings of effective combination therapy for breast cancer (reviewed in Olson, 2012) with pertuzumab (PDB: 1s78; Franklin et al., 2004) and trastuzumab (...
C. Hudis, C. Swanton, Y.Y. Janjigian, et al. A phase 1 study evaluating the combination of an allosteric AKT inhibitor (MK-2206) and trastuzumab in patients with HER2-positive solid tumors Breast Cancer Research, 15 (2013), p. R110 doi:10.1186/bcr3577 View in ScopusGoogle Scholar 100...
that contain active receptors for the protein known as 'human epidermal growth factor 2' (HER2). Such tumours can be treated by the drug trastuzumab (marketed as Herceptin). This is believed to be the first time a specific genetic risk factor for HER2 positive breast tumours has been found....