POEMS syndrome (POEMS) is a rare multi-system disease which is typically associated with polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes. We report herein a case of POEMS with progressive polyneuropathy resistant to high-dose intravenous immunoglobulin therapy who exper...
In pPCL, these genetic abnormalities are already present at diagnosis, whereas during the process of progression of monoclonal gammopathy of undetermined significance (MGUS) to MM and finally to sPCL, there is a gradual accumulation of genetic events, resulting in the acquisition of a more ...
How to manage Waldenstrom's macroglobulinemia C Buske1 and V Leblond2 Waldenstrom's macroglobulinemia (WM) is very distinct from other indolent lymphoma subtypes: by definition it is accompanied by a monoclonal IgM gammopathy; it presents always with bone marrow infiltration and often with clinical ...
Immunoglobulin light chain amyloidosis is a protein deposition disorder where the precursor protein represents a monoclonal immunoglobulin light or heavy chain. Deposition in viscera results in restrictive cardiomyopathy, nephrotic range proteinuria, demyelinating peripheral neuropathy, hepatomegaly and malabsorptio...
In conclusion, while stem-cell transplantation has shown promise in specific C3G cases linked to monoclonal gammopathy, comprehensive studies are needed to establish its efficacy and safety as a standard treatment option for C3G. The emerging field of regenerative medicine is rapidly advancing, and ...