40 Rituximab monotherapy is slow to act; an extended regimen (8 infusions) has better activity. A transient increase of serum IgM (IgM flare) is common, occurring in 30% to 80% of patients treated with rituximab or other anti-CD20 monoclonal antibodies, and may exacerbate IgM-related ...
17,18 N-glycosylation of κ LCs is more common in patients with AL amyloidosis than in those with monoclonal gammopathy of undetermined significance (MGUS) or multiple myeloma (MM) and can be readily detected in serum by mass spectrometry.19,20 These genetic and posttranslational characteristics ...
Immunoglobulin light chain amyloidosis is a protein deposition disorder where the precursor protein represents a monoclonal immunoglobulin light or heavy chain. Deposition in viscera results in restrictive cardiomyopathy, nephrotic range proteinuria, demyelinating peripheral neuropathy, hepatomegaly and malabsorptio...
63 In the remainder, CAD is commonly associated with an underlying clonal B-cell disorder similar to WAIHA. In a recent series of non–infection-related CAD patients (N = 89), 34% were found to have a B-cell lymphoma, and another 47% had monoclonal gammopathy of undetermined significance....
In pPCL, these genetic abnormalities are already present at diagnosis, whereas during the process of progression of monoclonal gammopathy of undetermined significance (MGUS) to MM and finally to sPCL, there is a gradual accumulation of genetic events, resulting in the acquisition of a more ...
Multiple myeloma (MM) is a heterogeneous disease with survival ranging from months to decades. The goal of ‘cure’ remains elusive for most patients, but has been shown to be possible, with durable remission and a transition to a plateau phase (analogous to monoclonal gammopathy of uncertain ...
63 In the remainder, CAD is commonly associated with an underlying clonal B-cell disorder similar to WAIHA. In a recent series of non–infection-related CAD patients (N = 89), 34% were found to have a B-cell lymphoma, and another 47% had monoclonal gammopathy of undetermined significance....